Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities

doi:10.1039/d1fo00972a

	Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities
	Feng, Zheling 1; Chen, Jiali 1; Feng, Lu 2,3; Chen, Cheng 1; Ye, Yang 2,3; Lin, Ligen 1
刊名	FOOD & FUNCTION
	2021-05-12
页码	10
ISSN号	2042-6496
DOI	10.1039/d1fo00972a
通讯作者	Lin, Ligen()
英文摘要	Ten new polyisoprenylated benzophenone derivatives, 4,8-epi-uralione F (1), 4,8-epi-uralione G (2), uralione S (3), coccinone J (4), 6-epi-coccinone C (5), coccinone I (6), 36-hydroxy-guttiferone J (7), multiftorone I (8), garciniagifolone F (9) and 36-hydroxy-garciniagifolone F (10), were isolated from the fruits of Garcinia cambogia, along with seven known analogues. The structures of the new compounds were established based on the detailed analysis of 1D and 2D nuclear magnetic resonance (NMR) spectra and high resolution electrospray ionization mass spectrometra (HRESIMS), and their absolute configurations were determined from the electronic circular dichroism (ECD) spectra. All the isolates were tested for their inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. The results indicated that compound 1 displayed a potent NO inhibitory effect with an IC50 value of 41.60 +/- 0.17 mu M. Furthermore, compound 1 suppressed inducible NO synthase (iNOS) expression in a dose-dependent manner through inhibiting the activation of nuclear factor-kappa B (NF-kappa B).
资助项目	National Natural Science Foundation of China[81872754] ; Science and Technology Development Fund, Macau SAR[0031/2019/A1] ; University of Macau[MYRG2018-00037-ICMS]
WOS关键词	(-)-HYDROXYCITRIC ACID ; HCA-SX ; FRUITS ; INFLAMMATION ; EXTRACTION ; XANTHONE ; WEIGHT ; INDICA
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000656555200001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297253]
专题	中国科学院上海药物研究所
通讯作者	Lin, Ligen
作者单位	1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Ave Univ, Taipa 999078, Macao, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Feng, Zheling,Chen, Jiali,Feng, Lu,et al. Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities[J]. FOOD & FUNCTION,2021:10.
APA	Feng, Zheling,Chen, Jiali,Feng, Lu,Chen, Cheng,Ye, Yang,&Lin, Ligen.(2021).Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities.FOOD & FUNCTION,10.
MLA	Feng, Zheling,et al."Polyisoprenylated benzophenone derivatives from Garcinia cambogia and their anti-inflammatory activities".FOOD & FUNCTION (2021):10.