Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling

doi:10.1055/a-1509-8624

	Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling
	Zhang, Lanfei 1,2; Zhang, Xiaofei 2; Cui, Yongmei 1; Yang, Chunhao 2
刊名	SYNTHESIS-STUTTGART
	2021-05-17
页码	12
关键词	picolinamide 3,3-difluoroindolines 3-fluoroindoles directing groups
ISSN号	0039-7881
DOI	10.1055/a-1509-8624
通讯作者	Cui, Yongmei(ymcui@shu.edu.cn) ; Yang, Chunhao(chyang@simm.ac.cn)
英文摘要	Herein, a direct method for the synthesis of 3-fluoroindoles and 3,3-difluoroindolines from easily accessible 2,2-difluoro-2-phenylethan1-amines is presented. This protocol was performed by Pd-catalyzed direct C-H/N-H coupling and employed picolinamide as a directing group. By controlling the temperature for this transformation, various 3,3-difluoroindolines and 3-fluoroindoles could be isolated with moderate to good yields.
资助项目	Science and Technology Commission of Shanghai Municipality[18431907100] ; State Key Laboratory of Drug Research[SIMM193ZZ-03] ; Science
WOS关键词	DECARBOXYLATIVE FLUORINATION ; INDOLE ; PICOLINAMIDE ; DERIVATIVES ; INHIBITORS ; TRIFLUOROMETHYLATION ; ALKENES ; ACIDS
WOS研究方向	Chemistry
语种	英语
出版者	GEORG THIEME VERLAG KG
WOS记录号	WOS:000661613500001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297188]
专题	中国科学院上海药物研究所
通讯作者	Cui, Yongmei; Yang, Chunhao
作者单位	1.Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Lanfei,Zhang, Xiaofei,Cui, Yongmei,et al. Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling[J]. SYNTHESIS-STUTTGART,2021:12.
APA	Zhang, Lanfei,Zhang, Xiaofei,Cui, Yongmei,&Yang, Chunhao.(2021).Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling.SYNTHESIS-STUTTGART,12.
MLA	Zhang, Lanfei,et al."Direct Approach to 3-Fluoroindoles and 3,3-Difluoroindolines from 2,2-Difluoro-2-phenylethan-1-amines via C-H/N-H Coupling".SYNTHESIS-STUTTGART (2021):12.