Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex

doi:10.1016/j.neuropharm.2020.108382

	Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex
	Zhang, Bing 1,2; Yang, Xili 1; Ye, Luyu 3; Liu, Rui 1; Ye, Binglu 1; Du, Weijia 1; Shen, Fuyi 1; Li, Qian 1; Guo, Fan 3,4; Liu, Jinqi 6
刊名	NEUROPHARMACOLOGY
	2021-08-15
卷号	194 页码:10
ISSN号	0028-3908
DOI	10.1016/j.neuropharm.2020.108382
通讯作者	Li, Yang(liyang@simm.ac.cn) ; Xu, Zhendong(btxzd123@51mch.com) ; Liu, Zhiqiang(liuzhiqiang@51mch.com)
英文摘要	The fast-onset antidepressant actions of ketamine at subanaesthetic doses have attracted enormous interest in psychiatric disease treatment. However, the severe psychotomimetic side effects foster an urgent need to deeply understand the fast-onset antidepressant mechanism of ketamine. Ketamine, as a non-competitive NMDAR antagonist, increases the overall excitability of the mPFC, which is presumed to be essential for the antidepressant action of ketamine. However, the underlying mechanism is still elusive. Here, our results showed that low concentration of ketamine increased the activity and the excitatory/inhibitory ratio of pyramidal neurons; these changes were accompanied by diminished interneurons activity in the mPFC. Moreover, ketamine induced increases in excitatory transmission and antidepressant-like effects, which might rely on the functional intact of GABAergic system in the mPFC. These results suggest a critical role of the mPFC GABAergic system in the fast antidepressant effects of a subanaesthetic dose ketamine.
资助项目	National Natural Science Foundation[81771188] ; National Natural Science Foundation[81901376] ; National Natural Science Foundation[31671049] ; National Natural Science Foundation[81971418] ; Fundamental Research Funds for the Central Universities[22120180534] ; Shanghai Municipal Commission of Health and Family Planning[201740072] ; Science and Technology Commission of Shanghai Municipality[14411966700] ; Science and Technology Commission of Shanghai Municipality[16411967400] ; Science and Technology Commission of Shanghai Municipality[19401930500] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040220] ; National Key R&D Program of China[2018ZX09711002]
WOS关键词	RECEPTOR GLUN2D SUBUNIT ; NMDA RECEPTORS ; ANTIDEPRESSANT ACTIONS ; CHRONIC STRESS ; INTERNEURONS ; INHIBITION ; EXPRESSION ; BLOCKADE ; SCHIZOPHRENIA ; OSCILLATIONS
WOS研究方向	Neurosciences & Neurology ; Pharmacology & Pharmacy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000662265600003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297135]
专题	中国科学院上海药物研究所
通讯作者	Li, Yang; Xu, Zhendong; Liu, Zhiqiang
作者单位	1.Tongji Univ, Shanghai First Matern & Infant Hosp, Dept Anesthesiol, Sch Med, Shanghai 201204, Peoples R China 2.Tongji Univ, Shanghai First Matern & Infant Hosp, Clin & Translat Res Ctr, Sch Med, Shanghai 201204, Peoples R China 3.Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Tongji Univ, Sch Med, Anesthesia & Brain Funct Res Inst, Shanghai 200082, Peoples R China 6.MacDuffie Sch, 66 Sch St, Granby, MA 01033 USA
推荐引用方式 GB/T 7714	Zhang, Bing,Yang, Xili,Ye, Luyu,et al. Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex[J]. NEUROPHARMACOLOGY,2021,194:10.
APA	Zhang, Bing.,Yang, Xili.,Ye, Luyu.,Liu, Rui.,Ye, Binglu.,...&Liu, Zhiqiang.(2021).Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex.NEUROPHARMACOLOGY,194,10.
MLA	Zhang, Bing,et al."Ketamine activated glutamatergic neurotransmission by GABAergic disinhibition in the medial prefrontal cortex".NEUROPHARMACOLOGY 194(2021):10.