Small-molecule fluorescence-based probes for interrogating major organ diseases

doi:10.1039/d0cs01183e

	Small-molecule fluorescence-based probes for interrogating major organ diseases
	Han, Hai-Hao 1,2; Tian, He, Jr.1,2; Zang, Yi 3; Sedgwick, Adam C.4; Li, Jia 3; Sessler, Jonathan L.4; He, Xiao-Peng 1,2; James, Tony D.5,6
刊名	CHEMICAL SOCIETY REVIEWS
	2021-07-07
页码	39
ISSN号	0306-0012
DOI	10.1039/d0cs01183e
通讯作者	Li, Jia(jli@simm.ac.cn) ; Sessler, Jonathan L.(sessler@cm.utexas.edu) ; He, Xiao-Peng(xphe@ecust.edu.cn) ; James, Tony D.(t.d.james@bath.ac.uk)
英文摘要	Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases.
资助项目	National Natural Science Foundation of China[21788102] ; National Natural Science Foundation of China[91853201] ; National Key Sci-Tech Special Projects of Infection Diseases of China[2018ZX10732202] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Program of Shanghai Science and Technology Committee[17520750100] ; Fundamental Research Funds for the Central Universities[222201717003] ; Programme of Introducing Talents of Discipline to Universities[B16017] ; China Postdoctoral Science Foundation[2020M681196] ; Royal Society ; Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University[2020ZD01] ; Robert A. Welch Foundation[F-0018]
WOS关键词	HYPOCHLOROUS ACID ; MONOAMINE-OXIDASE ; HYDROGEN-PEROXIDE ; AMYLOID PLAQUES ; MICE ; MODELS ; VISUALIZATION ; FLUCTUATION ; HEALTH ; BRAINS
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000670372900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296967]
专题	中国科学院上海药物研究所
通讯作者	Li, Jia; Sessler, Jonathan L.; He, Xiao-Peng; James, Tony D.
作者单位	1.East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 4.Univ Texas Austin, Dept Chem, 105 E 24th St,A5300, Austin, TX 78712 USA 5.Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England 6.Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Han, Hai-Hao,Tian, He, Jr.,Zang, Yi,et al. Small-molecule fluorescence-based probes for interrogating major organ diseases[J]. CHEMICAL SOCIETY REVIEWS,2021:39.
APA	Han, Hai-Hao.,Tian, He, Jr..,Zang, Yi.,Sedgwick, Adam C..,Li, Jia.,...&James, Tony D..(2021).Small-molecule fluorescence-based probes for interrogating major organ diseases.CHEMICAL SOCIETY REVIEWS,39.
MLA	Han, Hai-Hao,et al."Small-molecule fluorescence-based probes for interrogating major organ diseases".CHEMICAL SOCIETY REVIEWS (2021):39.