New bioactive peptides from the venom gland of a social hornet Vespa velutina

doi:10.1016/j.toxicon.2021.06.002

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 2012年后新成立研究组

	New bioactive peptides from the venom gland of a social hornet Vespa velutina
	Meng, Yi-Chuan ; Mo, Xiang-Gui ; He, Tian-Tian ; Wen, Xin-Xin ; Nieh, James-C ; Yang, Xin-Wang ; Tan, Ken 3
刊名	TOXICON
	2021
卷号	199 期号:x 页码:94-100
关键词	Vespa velutina Venom gland Antimicrobial peptides Antioxidative peptides
ISSN号	0041-0101
DOI	10.1016/j.toxicon.2021.06.002
英文摘要	Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for the design of novel antibiotics to combat microbial resistance. In this research, we identified four new peptides (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and UVVTX-Vp2b, respectively) from the venom of Vespa velutina, and tested their antimicrobial, antioxidant, and hemolytic effects. All four peptides showed scavenging ability against DPPH, ABTS+, and center dot OH free radicals. Of note, Vp1b strongly inhibited the growth of Staphylococcus aureus and Escherichia coli bacteria at concentrations of 60 and 120 mu M. Due to their low hemolytic activity, all four peptides could be utilized in the development of new antioxidants and as candidates for the design of novel antimicrobial agents.
学科主题	Pharmacology & Pharmacy ; Toxicology
语种	英语
WOS记录号	WOS:000675540600004
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/12321]
专题	西双版纳热带植物园_2012年后新成立研究组
作者单位	1.[Meng, Yi-Chuan 2.Mo, Xiang-Gui 3.Wen, Xin-Xin 4.Chinese Acad Sci, CAS Key Lab Trop Forest Ecol, Xishuangbanna Trop Bot Garden, Kunming 650000, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.[He, Tian-Tian 7.Kunming Med Univ, Fac Basic Med Sci, Dept Anat & Histol & Embryol, Kunming 650500, Yunnan, Peoples R China 8.Univ Calif San Diego, Div Biol Sci, Sect Ecol Behav & Evolut, La Jolla, CA 92093 USA
推荐引用方式 GB/T 7714	Meng, Yi-Chuan,Mo, Xiang-Gui,He, Tian-Tian,et al. New bioactive peptides from the venom gland of a social hornet Vespa velutina[J]. TOXICON,2021,199(x):94-100.
APA	Meng, Yi-Chuan.,Mo, Xiang-Gui.,He, Tian-Tian.,Wen, Xin-Xin.,Nieh, James-C.,...&Tan, Ken.(2021).New bioactive peptides from the venom gland of a social hornet Vespa velutina.TOXICON,199(x),94-100.
MLA	Meng, Yi-Chuan,et al."New bioactive peptides from the venom gland of a social hornet Vespa velutina".TOXICON 199.x(2021):94-100.