Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress

doi:10.1155/2020/9861571

CORC > 西双版纳热带植物园 > 中国科学院西双版纳热带植物园 > 2012年后新成立研究组

	Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress
	Chen Rui-rong ; Liu Juan ; Chen Zhe ; Cai Wen-jun ; Li Xiu-fen ; Lu Chuan-li
刊名	EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
	2020
卷号	2020 页码:-
关键词	ACUTE LIVER-INJURY PLANTS
ISSN号	1741-427X
DOI	10.1155/2020/9861571
英文摘要	In Southwestern China, the root of Morinda angustifolia Roxb. has been employed as a folk medicine for treating various types of hepatitis and jaundice. The purpose of this study was to evaluate the hepatoprotective effects of anthraquinones extract from M. angustifolia root (AEMA) in carbon tetrachloride- (CCl4-) induced liver injury in mice and identify the main bioactive components. Results indicated that AEMA pretreatment could significantly, in a dose-dependent manner, attenuate the increased levels of ALT and AST in mice serum induced by CCl4. At doses of 100 and 200 mg/kg, AEMA exhibited significant suppression of the elevated hepatic levels of malondialdehyde (MDA), as well as marked upregulatory effects on the activities of antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in mice exposed to CCl4. However, AEMA treatment had no effect on the antioxidant enzyme catalase (CAT) or the nonenzymatic antioxidant glutathione (GSH). Furthermore, two anthraquinone constituents were isolated from AEMA and identified as soranjidiol and rubiadin-3-methyl ether. Soranjidiol exhibited similar protective effects to those of AEMA on liver damage induced by CCl4. Overall, our research clearly demonstrated the hepatoprotective effects of the AEMA, and anthraquinones, particularly soranjidiol, should be considered as the main hepatoprotective principles of M. angustifolia. In addition, the underlying mechanism may be, at least in part, related to its antioxidant properties.
学科主题	Integrative & Complementary Medicine
语种	英语
WOS记录号	WOS:000526863200002
内容类型	期刊论文
源URL	[http://ir.xtbg.org.cn/handle/353005/11685]
专题	西双版纳热带植物园_2012年后新成立研究组
作者单位	1.Liu Juan 2.Guangdong Acad Sci, Guangdong Key Lab Sugarcane Improvement & Biorefi, Guangdong Bioengn Inst, Guangzhou Sugarcane Ind Res Inst, Guangzhou 510316, Peoples R China 3.[Chen Rui-rong 4.Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Yunnan, Peoples R China 5.[Chen Zhe 6.[Li Xiu-fen 7.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, Mengla 666303, Peoples R China 8.Cai Wen-jun
推荐引用方式 GB/T 7714	Chen Rui-rong,Liu Juan,Chen Zhe,et al. Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,2020:-.
APA	Chen Rui-rong,Liu Juan,Chen Zhe,Cai Wen-jun,Li Xiu-fen,&Lu Chuan-li.(2020).Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2020,-.
MLA	Chen Rui-rong,et al."Anthraquinones Extract from Morinda angustifolia Roxb. Root Alleviates Hepatic Injury Induced by Carbon Tetrachloride through Inhibition of Hepatic Oxidative Stress".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2020(2020):-.