Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A

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	Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A
	Zhang, Xiaoru; Zhang, Yaxian; Ji, Zhihua; Wang, Fengbang; Zhang, Lei; Song, Maoyong; Li, Hao
刊名	ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
	2020-11
卷号	80 页码:1-8
关键词	Tetrachlorobisphenol A Reactive oxygen species accumulation Signaling pathway Saccharomyces cerevisiae
ISSN号	1382-6689
英文摘要	Tetrachlombisphenol A (TCBPA) can promote intracellular reactive oxygen species (ROS) accumulation. However, limited attention has been given to mechanisms underlying TCBPA exposure-associated ROS accumulation. Here, such mechanisms were explored in the simple eukaryotic model organism Saccharomyces cerevisiae exposed to multiple concentrations of TCBPA. Addition of diphenyleneiodonium, a specific inhibitor of NADPH oxidase, blocked TCBPA treatment-associated intracellular ROS accumulation. NADPH oxidase can be activated by calcineurin, mitogen-activated protein kinase (MAPK), and tyrosine kinase. Therefore, corresponding specific inhibition respectively on these three kinases was performed and results suggested that the Ca2+ signaling pathway, MAPK pathway, and tyrosine kinase pathway all contributed to the TCBPA exposure-associated intracellular ROS accumulation. In addition, TCBPA exposure-associated up-regulation of genes involved in ROS production and down-regulation of catalase promoted ROS accumulation in S. cerevisiae. To sum up, our current results provide insights into the understanding of TCBPA exposure-associated ROS accumulation.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44881]
专题	生态环境研究中心_环境纳米材料实验室
推荐引用方式 GB/T 7714	Zhang, Xiaoru,Zhang, Yaxian,Ji, Zhihua,et al. Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2020,80:1-8.
APA	Zhang, Xiaoru.,Zhang, Yaxian.,Ji, Zhihua.,Wang, Fengbang.,Zhang, Lei.,...&Li, Hao.(2020).Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,80,1-8.
MLA	Zhang, Xiaoru,et al."Oxidative damage mechanism in Saccharomyces cerevisiae cells exposed to tetrachlorobisphenol A".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 80(2020):1-8.