Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads

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	Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads
	Yang, Lu; Shen, Qiuxuan; Zeng, Tao; Li, Jianzhong; Li, Wei; Wang, Yinghuan
刊名	ENVIRONMENTAL POLLUTION
	2020-03
卷号	258 页码:1-10
关键词	Lizards Neonicotinoids Endocrine disruption Imidacloprid
ISSN号	0269-7491
英文摘要	Soil contaminants can cause direct harm to lizards due to their regular swallowing of soil particles. As the world's fastest growing insecticide with long half-life in soil, the endocrine disrupting effect of neonicotinoids on lizards deserves more attention. In this report, we assessed the endocrine disrupting effect of imidacloprid on Eremias argus during 28 days of continuous exposure. Among the imidacloprid and its metabolites, only the metabolite 6-chloropyridic acid had a significant accumulation in the gonads and was positively correlated with its blood concentration. Imidacloprid might cause endocrine disrupting effects on lizards in two ways. First, the desnitro metabolites of imidacloprid could accumulate in the brain, inhibited the secretion of gonadotropin-releasing hormone, and ultimately affected the feedback regulation of hypothalamic-pituitary-gonadal related hormones. Secondly, imidacloprid severely inhibited the gene expression of the corresponding enzymes in the gonadal anti-oxidative stress system, causing histological damage to the gonads and ultimately affecting gonadal function. Specifically, exposure to imidacloprid resulted in abnormal arrangement of spermatogenic epithelial epithelium, hyperplasia of epididymal wall, and oligospermia of male lizard. Meanwhile, gene expressions of cyp17, cyp19, and hsd1713 were severely inhibited in the imidacloprid exposure group, consistent with decreased levels of testosterone and estradiol in plasma. Imidacloprid exposure could cause insufficient androgen secretion and less spermatogenesis in male lizards. The risk of imidacloprid exposure to female lizards was not as severe as that of male lizards, but it still inhibited the expression of cyp19 in the ovaries and led to a decrease in the synthesis of estradiol. This study firstly reported the endocrine disruption of imidacloprid to lizards, providing new data for limiting the use of neonicotinoids. (C) 2019 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/45164]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
推荐引用方式 GB/T 7714	Yang, Lu,Shen, Qiuxuan,Zeng, Tao,et al. Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads[J]. ENVIRONMENTAL POLLUTION,2020,258:1-10.
APA	Yang, Lu,Shen, Qiuxuan,Zeng, Tao,Li, Jianzhong,Li, Wei,&Wang, Yinghuan.(2020).Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads.ENVIRONMENTAL POLLUTION,258,1-10.
MLA	Yang, Lu,et al."Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads".ENVIRONMENTAL POLLUTION 258(2020):1-10.