Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries
	Bai, Xue; Wang, Shenqing; Yan, Xiliang; Zhou, Hongyu; Zhan, Jinhua; Liu, Sijin; Sharma, Virender K.; Jiang, Guibin; Zhu, Hao; Yan, Bing
刊名	ACS NANO
	2020-01
卷号	14 期号:1 页码:289-302
关键词	core material nanoparticle library nanohydrophobicity nano redox activity cell fate
ISSN号	1936-0851
英文摘要	Nanoparticle structural parameters, such as size, surface chemistry, and shape, are well-recognized parameters that affect biological activities of nanoparticles. However, whether the core material of a nanoparticle also plays a role remains unknown. To answer this long-standing question, we synthesized and investigated a comprehensive library of 36 nanoparticles with all combinations of three types of core materials (Au, Pt, and Pd), two sizes (6 and 26 nm), and each conjugated with one of six surface ligands of different hydrophobicity. Using this systematic approach, we were able to identify cellular perturbation specifically attributed to core, size, or surface ligand. We discovered that core materials exhibited a comparable regulatory ability as surface ligand on cellular ROS generation and cytotoxicity. Pt nanoparticles were much more hydrophilic and showed much less cell uptake compared to Au and Pd nanoparticles with identical size, shape, and surface ligands. Furthermore, diverse core materials also regulated levels of cellular redox activities, resulting in different cytotoxicity. Specifically, Pd nanoparticles significantly reduced cellular H2O2 and promoted cell survival, while Au nanoparticles with identical size, shape, and surface ligand induced higher cellular oxidative stress and cytotoxicity. Our results demonstrate that nanoparticle core material is as important as other structural parameters in nanoparticle-cell interactions, making it also a necessary consideration when designing nanomedicines.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44793]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Bai, Xue,Wang, Shenqing,Yan, Xiliang,et al. Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries[J]. ACS NANO,2020,14(1):289-302.
APA	Bai, Xue.,Wang, Shenqing.,Yan, Xiliang.,Zhou, Hongyu.,Zhan, Jinhua.,...&Yan, Bing.(2020).Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries.ACS NANO,14(1),289-302.
MLA	Bai, Xue,et al."Regulation of Cell Uptake and Cytotoxicity by Nanoparticle Core under the Controlled Shape, Size, and Surface Chemistries".ACS NANO 14.1(2020):289-302.