First In Vivo Evidence for Compromised Brain Energy Metabolism upon Intranasal Exposure to ZnO Nanoparticles

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	First In Vivo Evidence for Compromised Brain Energy Metabolism upon Intranasal Exposure to ZnO Nanoparticles
	Guo, Zhiling; Zhang, Peng; Xie, Heidi Qunhui; Zhao, Bin; Lynch, Iseult
刊名	ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
	2020-05-12
卷号	7 期号:5 页码:315-322
ISSN号	2328-8930
英文摘要	Previous studies indicate that exposure to zinc oxide nanoparticles (ZnO NPs) may potentially cause brain damage in mammals; however, the mechanism remains unclear. In particular, their effect on brain energy metabolism, which is essential for maintaining brain function, is unknown. This study demonstrates that intranasal exposure to ZnO NPs causes a decrease in the relative brain weight of rats and induces structural and pathological changes in the brain. Multiomics data consistently demonstrate the alteration of energy metabolism in the brain, including upregulated glycolysis, a downregulated tricarboxylic acid cycle, and oxidative phosphorylation, as well as downregulated fatty acid beta-oxidation, an alternative pathway for an energy supply. As a result, the adenosine triphosphate (ATP) levels in the brain are depressed. ZnSO4 exposure results in similar Zn accumulation, identical Zn chemical species, and similar patterns of effects on the brain compared to ZnO NPs, suggesting that the effects observed in the ZnO NP group are mainly caused by the released Zn2+. This study provides the first in vivo evidence for compromised brain energy metabolism induced by ZnO NPs. Further studies are thus imperative to explore the longer-term consequences of the compromised brain energy metabolism and the origin of the toxic effects and to expand to other NPs.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44690]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Guo, Zhiling,Zhang, Peng,Xie, Heidi Qunhui,et al. First In Vivo Evidence for Compromised Brain Energy Metabolism upon Intranasal Exposure to ZnO Nanoparticles[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,2020,7(5):315-322.
APA	Guo, Zhiling,Zhang, Peng,Xie, Heidi Qunhui,Zhao, Bin,&Lynch, Iseult.(2020).First In Vivo Evidence for Compromised Brain Energy Metabolism upon Intranasal Exposure to ZnO Nanoparticles.ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS,7(5),315-322.
MLA	Guo, Zhiling,et al."First In Vivo Evidence for Compromised Brain Energy Metabolism upon Intranasal Exposure to ZnO Nanoparticles".ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS 7.5(2020):315-322.