Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials
	Guo, Zhiling; Zhang, Peng; Chetwynd, Andrew J.; Xie, Heidi Qunhui; Valsami-Jones, Eugenia; Zhao, Bin; Lynch, Iseult
刊名	NANOSCALE
	2020-09-28
卷号	12 期号:36 页码:18600-18605
ISSN号	2040-3364
英文摘要	Graphene family nanomaterials (GFNs) have shown great potential for biological and environmental applications; however, their future use has been debated due to their reported potential neurotoxicity. Moreover, the effects of surface functionalization on their biological end points are largely unknown. Here, we compared the effects of reduced graphene oxide (RGO), and carboxylated (G-COOH), hydroxylated (G-OH) and aminated (G-NH2) graphene nanosheets on human neuroblastoma cells (SK-N-SH). All GFNs inhibited cellular growth at concentrations of 0.1-10 mg L(-1)after 24 h exposure. The toxicity was attenuated over longer exposure times, with the exception of G-NH2. Although the overall acute toxicity followed the order: G-OH approximate to G-COOH > RGO > G-NH2, G-NH(2)induced more persistent toxicity and more metabolic disturbance compared to the other GFNs, with lipid and carbohydrate metabolism being the most affected. The potential for physical disruption of the lipid membrane and oxidative damage induced by GFNs varied with different functionalization, which accounts for the observed differences in neurotoxicity. This study provides significant insights into the neurological effects of GFNs, and suggests that G-NH(2)is not as safe as reported in many previous studies. The neurological effect of GFNs over longer term exposure should be considered in future studies.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44670]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Guo, Zhiling,Zhang, Peng,Chetwynd, Andrew J.,et al. Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials[J]. NANOSCALE,2020,12(36):18600-18605.
APA	Guo, Zhiling.,Zhang, Peng.,Chetwynd, Andrew J..,Xie, Heidi Qunhui.,Valsami-Jones, Eugenia.,...&Lynch, Iseult.(2020).Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials.NANOSCALE,12(36),18600-18605.
MLA	Guo, Zhiling,et al."Elucidating the mechanism of the surface functionalization dependent neurotoxicity of graphene family nanomaterials".NANOSCALE 12.36(2020):18600-18605.