Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans
	Wei, Shuting; Liu, Wei; Qi, Yu; Guo, Yifan; Zhang, Shuping; Wang, Li; Zhuang, Taifeng; Zhang, Na; Liu, Sijin
刊名	BRITISH JOURNAL OF HAEMATOLOGY
	2020-02
卷号	192 期号:3 页码:643-651
关键词	erythroferrone hepcidin iron spontaneous abortion early pregnancy
ISSN号	0007-1048
英文摘要	Spontaneous abortion is a common, detrimental outcome of pregnancy, and can be induced by a variety of factors, including pathophysiological conditions and socioeconomic circumstances. Despite numerous studies examining the aetiology of spontaneous abortion, there is limited understanding of the disordered iron transportation between mother and fetus through the placenta. Recently, erythroferrone (ERFE) was recognized as a novel negative regulator of hepcidin that can elevate nutritional iron absorption and macrophagic iron egress for enhanced erythropoiesis. However, its diagnostic significance in different disease conditions associated with iron remains poorly understood. In the current study, we discovered disordered maternal iron homeostasis in women who had spontaneous abortions during early pregnancy, as characterized by increased serum iron and hepcidin levels, and conversely, reduced serum ERFE levels, compared to healthy control individuals and women with normal pregnancy. Comprehensive statistical analyses revealed the correlation between different variables and pregnancy status, signifying the pronounced diagnostic value of an increased ratio of serum hepcidin and ERFE (HE ratio) in recognizing adverse pregnancy status. In contrast to previous non-selective discrete surrogates, such as iron, hepcidin and ferritin, the HE ratio may otherwise stand for a novel and more representative hallmark for early spontaneous abortion.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44658]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Wei, Shuting,Liu, Wei,Qi, Yu,et al. Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans[J]. BRITISH JOURNAL OF HAEMATOLOGY,2020,192(3):643-651.
APA	Wei, Shuting.,Liu, Wei.,Qi, Yu.,Guo, Yifan.,Zhang, Shuping.,...&Liu, Sijin.(2020).Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans.BRITISH JOURNAL OF HAEMATOLOGY,192(3),643-651.
MLA	Wei, Shuting,et al."Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans".BRITISH JOURNAL OF HAEMATOLOGY 192.3(2020):643-651.