Cadmium-binding proteins in human blood plasma

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Cadmium-binding proteins in human blood plasma
	Li, Yiling; Huang, Yong-shun; He, Bin; Liu, Runzeng; Qu, Guangbo; Yin, Yongguang; Shi, Jianbo; Hu, Ligang; Jiang, Guibin
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2020-01-30
卷号	188 页码:1-8
关键词	Cadmium-binding proteins Normal human plasma Maternal plasma Umbilical cord plasma
ISSN号	0147-6513
英文摘要	Blood is the transmission medium for metal contaminants to and from bodily organs; as such, it can provide useful and reliable information about their bio-kinetics as they're distributed throughout the body. Metals can interact with endogenous proteins present in the blood, and these metal-protein complexes often dictate the fates of the introduced metals. The aim of this study was to investigate cadmium-binding protein characteristics in normal human plasma. Cadmium-binding plasma proteins in two different groups: normal human plasma (n = 29), and normal paired maternal and fetal umbilical cord plasmas (n = 3), were analyzed. In order to detect cadmium-binding plasma proteins present in low concentrations, blood plasma samples were first depleted of their two most abundant proteins - albumin and immunoglobulin G. Both the crude and depleted plasma samples were analyzed using column gel electrophoresis in conjunction with Inductively Coupled Plasma-Mass Spectrometry (ICP-MS). One cadmium-binding protein was detected in 11 of 29 normal plasma samples and all three paired maternal and cord plasma samples. This protein was further identified as apolipoprotein A-I by high-resolution mass spectrometry. To the best of our knowledge, this is the first study to reveal cadmium-binding proteins in real human blood plasma, which is extremely critical to our understanding of cadmium transportation and accumulation in human blood.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44626]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Yiling,Huang, Yong-shun,He, Bin,et al. Cadmium-binding proteins in human blood plasma[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2020,188:1-8.
APA	Li, Yiling.,Huang, Yong-shun.,He, Bin.,Liu, Runzeng.,Qu, Guangbo.,...&Jiang, Guibin.(2020).Cadmium-binding proteins in human blood plasma.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,188,1-8.
MLA	Li, Yiling,et al."Cadmium-binding proteins in human blood plasma".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 188(2020):1-8.