2,2 ',4,4 '-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis)

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	2,2 ',4,4 '-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis)
	Li, Jin-Bo; Li, Yuan-Yuan; Shen, Yan-Ping; Zhu, Min; Li, Xing-Hong; Qin, Zhan-Fen
刊名	AQUATIC TOXICOLOGY
	2020-04
卷号	221 页码:1-9
关键词	BDE-47 Gonadal development Xenopus laevis Feminization
ISSN号	0166-445X
英文摘要	Previous studies have shown that BDE-47, one of the most abundant polybrominated diphenyl ethers (PBDEs) congeners, has a weak estrogenic activity, but it has remained unclear whether BDE-47 disrupts gonadal development and causes male-to-female sex reversal in lower vertebrates, with limited and controversial data. The present study aimed to determine the effects of BDE-47 on gonadal development in Xenopus laevis, a model amphibian species for studying adverse effects of estrogenic chemicals on reproductive development. X. laevis at stage 45/46 were exposed to BDE-47 (0.5, 5, 50 nM) in semi-static system, with 1 nM 17 beta-estradiol (E2) as the positive control. When reaching stage 53, tadpoles were examined for gonadal morphology, histology and sex-dimorphic gene expression. The phenotypic sex (gonadal morphology and histology) of each BDE-47-treated tadpole matched its genetic sex, showing no sex-reversal, whereas one half of genetic males treated with E2 displayed ovarian-like features. However, some genetic males (26%) in the 50 nM BDE-47 treatment group were found to contain more germ cells clumping together in the medulla, along with an increasing tendency of the gonad length/kidney length ratio in males, resembling feminizing outcomes of E2. These observations seem to suggest that BDE-47 exerted weak feminizing effects. However, BDE-47 induced increases in expression of both female-biased genes and male-biased genes in two sexes, which disagrees with feminizing outcomes, suggesting complicated effects of BDE-47 on gonadal development. Taken together, all results demonstrate that nanomolar BDE-47 disrupted gonadal development and exerted weak feminizing effects, but not resulted in male-to-female sex reversal in X. laevis.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/44571]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Jin-Bo,Li, Yuan-Yuan,Shen, Yan-Ping,et al. 2,2 ',4,4 '-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis)[J]. AQUATIC TOXICOLOGY,2020,221:1-9.
APA	Li, Jin-Bo,Li, Yuan-Yuan,Shen, Yan-Ping,Zhu, Min,Li, Xing-Hong,&Qin, Zhan-Fen.(2020).2,2 ',4,4 '-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis).AQUATIC TOXICOLOGY,221,1-9.
MLA	Li, Jin-Bo,et al."2,2 ',4,4 '-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis)".AQUATIC TOXICOLOGY 221(2020):1-9.