Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation

	Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation
	Chen, Qing-An 1; Gao, Kai 1; Duan, Ying 1; Ye, Zhi-Shi 1; Shi, Lei 1; Yang, Yan 1; Zhou, Yong-Gui 1,2
刊名	journal of the american chemical society
	2012-02-01
卷号	134 期号:4 页码:2442-2448
通讯作者	周永贵
产权排序	1,1
英文摘要	a new and easily regenerable nad(p)h model 9,10-dihydrophenanthridine (dhpd) has been designed for biomimetic asymmetric hydrogenation of imines and aromatic compounds. this reaction features the use of hydrogen gas as terminal reductant for the regeneration of the dhpd under the mild condition. therefore, the substrate scope is not limited in benzoxazinones; the biomimetic asymmetric hydrogenation of benzoxazines, quinoxafines, and quinolines also gives excellent activities and enantioselectivities. meanwhile, an unexpected reversal of enantioselectivity was observed between the reactions promoted by the different nad(p)h models, which is ascribed to the different hydride transfer pathway.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	enantioselective transfer hydrogenation ; organocatalytic transfer hydrogenation ; iridium-catalyzed hydrogenation ; bronsted acid catalysis ; alpha-imino esters ; chiral phosphoric-acids ; n-h ketimines ; hantzsch esters ; heteroaromatic-compounds ; reductive amination
收录类别	SCI ; IC ; CCR
语种	英语
WOS记录号	WOS:000301084600085
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/118376]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
推荐引用方式 GB/T 7714	Chen, Qing-An,Gao, Kai,Duan, Ying,et al. Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation[J]. journal of the american chemical society,2012,134(4):2442-2448.
APA	Chen, Qing-An.,Gao, Kai.,Duan, Ying.,Ye, Zhi-Shi.,Shi, Lei.,...&Zhou, Yong-Gui.(2012).Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation.journal of the american chemical society,134(4),2442-2448.
MLA	Chen, Qing-An,et al."Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation".journal of the american chemical society 134.4(2012):2442-2448.