A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides

	A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
	Zhu, Zhiwei 1,2; Zhang, Sufang 1,3; Liu, Hongwei 4; Shen, Hongwei 1,3; Lin, Xinping 1,2; Yang, Fan 1,5; Zhou, Yongjin J.1,2; Jin, Guojie 1,2; Ye, Mingliang 4; Zou, Hanfan 4
刊名	nature communications
	2012-10-01
卷号	3 页码:1112
ISSN号	2041-1723
通讯作者	邹汉法 ; 赵宗保
产权排序	1, 1
英文摘要	triacylglycerols are among the most attractive alternative raw materials for biofuel development. current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. these limitations may be circumvented by biotransformation of carbohydrates into lipids; however, our understanding of microbial oleaginicity remains limited. here we present the results of a multi-omic analysis of rhodosporidium toruloides, a robust triacylglycerol-producing fungus. the assembly of genome and transcriptome sequencing data reveals a genome of 20.2 m mb containing 8,171 protein-coding genes, the majority of which have multiple introns. genes including a novel fatty acid synthase are predicted to participate in metabolic pathways absent in non-oleaginous yeasts. transcriptomic and proteomic data suggest that lipid accumulation under nitrogen-limited conditions correlates with the induction of lipogenesis, nitrogenous compound recycling, macromolecule metabolism and autophagy. the multi-omic map of r. toruloides therefore provides a valuable resource for efforts to rationally engineer lipid-production pathways.
学科主题	物理化学
WOS标题词	science & technology
类目[WOS]	multidisciplinary sciences
研究领域[WOS]	science & technology - other topics
关键词[WOS]	fatty-acid synthase ; atp-citrate lyase ; oleaginous yeast ; aspergillus-nidulans ; malic enzyme ; rna-seq ; accumulation ; metabolism ; purification ; genome
收录类别	SCI
语种	英语
WOS记录号	WOS:000313514100022
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/118298]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Div Biotechnol, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 3.Dalian Natl Lab Clean Energy, Div Biomass Convers & Bioenergy, Dalian 116023, Peoples R China 4.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China 5.Dalian Polytech Univ, Sch Biol Engn, Dalian 116034, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Zhiwei,Zhang, Sufang,Liu, Hongwei,et al. A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides[J]. nature communications,2012,3:1112.
APA	Zhu, Zhiwei.,Zhang, Sufang.,Liu, Hongwei.,Shen, Hongwei.,Lin, Xinping.,...&Zhao, Zongbao K..(2012).A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.nature communications,3,1112.
MLA	Zhu, Zhiwei,et al."A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides".nature communications 3(2012):1112.