Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9

	Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9
	Zhu, Liangliang 1,2; Ge, Guangbo 1; Liu, Yong 1; He, Guiyuan 1,2; Liang, Sicheng 1; Fang, Zhongze 1,2; Dong, Peipei 3; Cao, Yunfeng 1; Yang, Ling 1
刊名	xenobiotica
	2012-10-01
卷号	42 期号:10 页码:1001-1008
关键词	Magnolol UDP-glucuronosyltransferases glucuronidation UGT inhibitor
通讯作者	杨凌
产权排序	1,1
英文摘要	1. human exposure to magnolol can reach a high dose in daily life. our previous studies indicated that magnolol showed high affinities to several udp-glucuronosyltransferases (ugts) this study was designed to examine the in vitro inhibitory effects of magnolol on ugts, and further to evaluate the possibility of the in vivo inhibition that might happen.
学科主题	物理化学
类目[WOS]	pharmacology & pharmacy ; toxicology
研究领域[WOS]	pharmacology & pharmacy ; toxicology
关键词[WOS]	human udp-glucuronosyltransferases ; human liver-microsomes ; in-vitro ; glucuronidation ; kinetics ; androsterone ; specificity ; enzymes ; single ; ugt2b7
收录类别	SCI
语种	英语
WOS记录号	WOS:000308411600006
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/118185]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Dalian Med Univ, Res Inst Integrated Tradit & Western Med, Dalian, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Liangliang,Ge, Guangbo,Liu, Yong,et al. Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9[J]. xenobiotica,2012,42(10):1001-1008.
APA	Zhu, Liangliang.,Ge, Guangbo.,Liu, Yong.,He, Guiyuan.,Liang, Sicheng.,...&Yang, Ling.(2012).Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9.xenobiotica,42(10),1001-1008.
MLA	Zhu, Liangliang,et al."Potent and selective inhibition of magnolol on catalytic activities of UGT1A7 and 1A9".xenobiotica 42.10(2012):1001-1008.