Persistent moderate to severe pain and long-term cognitive decline

doi:10.1002/ejp.1826

	Persistent moderate to severe pain and long-term cognitive decline
	Rong, Wei 1; Zhang, Cheng 2; Zheng, Fanfan 3; Xiao, Songhua 1; Yang, Zhenchun 4; Xie, Wuxiang 5,6
刊名	EUROPEAN JOURNAL OF PAIN
	2021-07-05
页码	10
ISSN号	1090-3801
DOI	10.1002/ejp.1826
通讯作者	Xie, Wuxiang(xiewuxiang@hsc.pku.edu.cn)
英文摘要	Background The longitudinal association between persistent moderate to severe pain and subsequent long-term cognitive decline remains inconclusive. Methods Study population came from the English Longitudinal Study of Ageing, an ongoing prospective and nationally representative cohort of community-dwelling adults aged >= 50 years in England. At waves 1 (2002/2003) and 2 (2004/2005) of the study, pain severity was measured based on pain intensity scores ranged from 0 to 10. We defined moderate to severe pain as pain intensity scores >= 5 points. Persistent moderate to severe pain was defined as participants reported moderate to severe pain at both waves 1 and 2. Standardized global cognitive Z scores derived from verbal memory, temporal orientation and semantic fluency were used as the primary outcome. Results A total of 6,869 individuals (3,896 women; mean age: 63.9 +/- 9.5 years) who have accepted twice measurements of pain at waves 1 and 2 (baseline), and at least one reassessment of cognitive function at waves 3 (2006/2007) to 8 (2016/2017), were included in this study. Each 5-point increase in the sum of pain intensity scores was associated with a faster rate of -0.009 (95% CI: -0.013 to -0.006, p < .001) in global cognitive Z scores. Compared with no pain group, persistent moderate to severe pain group was associated with a significantly faster decline rate of -0.031 SD/year (95% CI: -0.043 to -0.018), in global cognitive Z scores. The relationships of persistent moderate to severe pain with verbal memory, temporal orientation and semantic fluency were similar. Conclusion Cognitive function should be monitored in individuals with persistent moderate to severe pain. Significance Persistent moderate to severe pain in adults age 50 and older was associated with accelerated cognitive decline over a median follow-up of 12 years. More severe pain was associated with faster cognitive decline in a dose-response pattern, and the relationship was demonstrated throughout multiple cognitive domains. While the overall effect was subtle, clinicians should be aware that older adults with persistent pain are at risk of faster cognitive decline.
资助项目	National Natural Science Foundation of China[81974490] ; Beijing Natural Science Foundation[7182108] ; Newton International Fellowship from the Academy of Medical Sciences, UK[NIF001-1005-P56804] ; 2019 Irma and Paul Milstein Program for Senior Health Research Project Award
WOS关键词	OPIOIDS ; PREVALENCE ; DEMENTIA
WOS研究方向	Anesthesiology ; Neurosciences & Neurology
语种	英语
出版者	WILEY
WOS记录号	WOS:000669746400001
资助机构	National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Newton International Fellowship from the Academy of Medical Sciences, UK ; 2019 Irma and Paul Milstein Program for Senior Health Research Project Award
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/45243]
专题	自动化研究所_脑网络组研究中心
通讯作者	Xie, Wuxiang
作者单位	1.Tsinghua Univ, Beijing Tsinghua Changgung Hosp, Dept Orthoped, Med Ctr, Beijing, Peoples R China 2.Chinese Acad Sci, Beijing Key Lab Bioelectromagnetism, Inst Elect Engn, Beijing, Peoples R China 3.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 4.Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England 5.Peking Univ, Clin Res Inst, Hosp 1, 8 Xishiku St, Beijing 100034, Peoples R China 6.Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Rong, Wei,Zhang, Cheng,Zheng, Fanfan,et al. Persistent moderate to severe pain and long-term cognitive decline[J]. EUROPEAN JOURNAL OF PAIN,2021:10.
APA	Rong, Wei,Zhang, Cheng,Zheng, Fanfan,Xiao, Songhua,Yang, Zhenchun,&Xie, Wuxiang.(2021).Persistent moderate to severe pain and long-term cognitive decline.EUROPEAN JOURNAL OF PAIN,10.
MLA	Rong, Wei,et al."Persistent moderate to severe pain and long-term cognitive decline".EUROPEAN JOURNAL OF PAIN (2021):10.