Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging

doi:10.1166/jbn.2021.3124

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging
	Wang, Yaqin 1; Shang, Wenting 2; Xiong, Jianping 3; Liu, Yu 2; Luo, Ting 1; Qi, Xun 1,4; Niu, Meng 1; Xu, Ke 1
刊名	JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
	2021-07-01
卷号	17 期号:7 页码:1339-1348
关键词	GSH imaging Tumor Invasiveness Resistance Heterogenetic Nanoparticle Ratiometric Photoacoustic Imaging
ISSN号	1550-7033
DOI	10.1166/jbn.2021.3124
通讯作者	Qi, Xun(qixun716@hotmail.com) ; Niu, Meng(guanjh@cmu.edu.cn) ; Xu, Ke(kxu@cmu.edu.cn)
英文摘要	Studies have shown that a higher GSH level is related to more drug-resistant and invasiveness of a tumor. However, it is a great challenge to accurately imaging the GSH level in vivo, for its imaging intensity will interfered by different accumulation of probes in the tumor. Thus, we hypothesized ratiometric photoacoustic imaging that can be used to predict the drug-resistant and invasiveness of tumors by accurate GSH level imaging. In this study, we synthesized MnO2/Indocyanine Green (MnO2/ICG). It can be used as ratiometric photoacoustic (PA) imaging probe, for its absorption at 780 nm (Ab(780)) can be decreased and 680 nm (Ab(680)) remain unchanged upon GSH reduction. And our results confirmed that a lower PA absorption ratio (Ab(780)/Ab(680)) corresponded to a higher GSH level of the tumor. Besides, the near-infrared fluorescence (FI) imaging was used as an assistant, for it can be quenched upon GSH. Therefore, MnO2/ICG can predict the tumor invasiveness and drug resistance by imaging the GSH level. This study provides reference to predict the prognosis of tumors by imaging the metabolic biomarker of tumors.
资助项目	National Key Research and Development Program of China[2019YFC0118100] ; National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81630053] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81601584] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200]
WOS关键词	CANCER ; AMPLIFICATION ; THERAPY ; CELLS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER SCIENTIFIC PUBLISHERS
WOS记录号	WOS:000691557400002
资助机构	National Key Research and Development Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/45908]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Qi, Xun; Niu, Meng; Xu, Ke
作者单位	1.China Med Univ, Dept Intervent Radiol, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China 2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Acad Med Sci & Peking Union Med Coll, Dept Pancreat & Gastr Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing 100000, Peoples R China 4.China Med Univ, Dept Radiol, Key Lab Diagnost Imaging & Intervent Radiol Liaon, Affiliated Hosp 1, Shenyang 110000, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yaqin,Shang, Wenting,Xiong, Jianping,et al. Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(7):1339-1348.
APA	Wang, Yaqin.,Shang, Wenting.,Xiong, Jianping.,Liu, Yu.,Luo, Ting.,...&Xu, Ke.(2021).Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(7),1339-1348.
MLA	Wang, Yaqin,et al."Activable Nanoparticle for Tumor Aggressiveness and Drug Resistance Prediction by Glutathione Heterogeneous Imaging".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.7(2021):1339-1348.