Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function

	Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function
	Fu, Ting 1,2,3; Min, Hanyi 4,5; Xu, Yong 6; Chen, Jianzhong 7; Li, Guohui 1
刊名	international journal of molecular sciences
	2012-08-01
卷号	13 期号:8 页码:9709-9740
关键词	p53 MDM2 MDMX molecular dynamic simulation conformational change protein-protein interaction protein-ligand interaction
ISSN号	1661-6596
通讯作者	李国辉
产权排序	1,1
英文摘要	as a tumor suppressor protein, p53 plays a crucial role in the cell cycle and in cancer prevention. almost 50 percent of all human malignant tumors are closely related to a deletion or mutation in p53. the activity of p53 is inhibited by over-active celluar antagonists, especially by the over-expression of the negative regulators mdm2 and mdmx. protein-protein interactions, or post-translational modifications of the c-terminal negative regulatory domain of p53, also regulate its tumor suppressor activity. restoration of p53 function through peptide and small molecular inhibitors has become a promising strategy for novel anti-cancer drug design and development. molecular dynamics simulations have been extensively applied to investigate the conformation changes of p53 induced by protein-protein interactions and protein-ligand interactions, including peptide and small molecular inhibitors. this review focuses on the latest md simulation research, to provide an overview of the current understanding of interactions between p53 and its partners at an atomic level.
学科主题	物理化学
WOS标题词	science & technology ; physical sciences
类目[WOS]	chemistry, multidisciplinary
研究领域[WOS]	chemistry
关键词[WOS]	tumor-suppressor protein ; dna-binding domain ; n-terminal domain ; nuclear-magnetic-resonance ; structure-based design ; p53-mdm2 interaction ; transactivation domain ; crystal-structure ; s100 family ; mdm2-p53 interaction
收录类别	SCI
语种	英语
WOS记录号	WOS:000308243400023
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117955]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Mol Modeling & Design, State Key Lab Mol React Dynam, Dalian 116023, Peoples R China 2.Dalian Univ Technol, Dept Biosci & Biotechnol, Dalian 116024, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China 4.Chinese Acad Med Sci, Dept Ophthalmol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China 5.Peking Union Med Coll, Beijing 100730, Peoples R China 6.Chinese Acad Sci, Inst Biol Chem, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Guangdong, Peoples R China 7.Shanghai Jiao Tong Univ, Dept Math & Phys, Jinan 250031, Peoples R China
推荐引用方式 GB/T 7714	Fu, Ting,Min, Hanyi,Xu, Yong,et al. Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function[J]. international journal of molecular sciences,2012,13(8):9709-9740.
APA	Fu, Ting,Min, Hanyi,Xu, Yong,Chen, Jianzhong,&Li, Guohui.(2012).Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function.international journal of molecular sciences,13(8),9709-9740.
MLA	Fu, Ting,et al."Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function".international journal of molecular sciences 13.8(2012):9709-9740.