Single cell imaging with near-field terahertz scanning microscopy

doi:10.1111/cpr.12788

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Single cell imaging with near-field terahertz scanning microscopy
	Li, ZX ; Yan, SH ; Zang, ZY ; Geng, GS ; Yang, ZB ; Li, J ; Wang, LH ; Yao, CY ; Cui, HL ; Chang, C
刊名	CELL PROLIFERATION
	2020
卷号	53 期号:4 页码:-
关键词	TIME SPECTROSCOPY DYNAMICS INSIGHTS GROWTH WATER
ISSN号	0960-7722
DOI	10.1111/cpr.12788
文献子类	期刊论文
英文摘要	Objectives Terahertz (THz)-based imaging techniques hold great potential for biological and biomedical applications, which nevertheless are hampered by the low spatial resolution of conventional THz imaging systems. In this work, we report a high-performance photoconductive antenna microprobe-based near-field THz time-domain spectroscopy scanning microscope. Materials and methods A single watermelon pulp cell was prepared on a clean quartz slide and covered by a thin polyethylene film. The high performance near-field THz microscope was developed based on a coherent THz time-domain spectroscopy system coupled with a photoconductive antenna microprobe. The sample was imaged in transmission mode. Results We demonstrate the direct imaging of the morphology of single watermelon pulp cells in the natural dehydration process with our near-field THz microscope. Conclusions Given the label-free and non-destructive nature of THz detection techniques, our near-field microscopy-based single-cell imaging approach sheds new light on studying biological samples with THz.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33137]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Third Mil Med Univ, Southwest Hosp, Dept Transfus Med, Army Med Univ, Chongqing 400038, Peoples R China 2.Chinese Acad Sci, Ctr Appl Phys, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China 3.Chinese Acad Sci, Chongqing Engn Res Ctr High Resolut & Three Dimen, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China 4.Jilin Univ, Coll Instrumentat & Elect Engn, Changchun, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai, Peoples R China 6.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Shanghai Synchrotron Radiat Facil,Bioimaging Ctr, Shanghai, Peoples R China 7.Tsinghua Univ, Dept Engn Phys, Beijing, Peoples R China 8.Natl Innovat Inst Def Technol, Adv Interdisciplinary Technol Res Ctr, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, ZX,Yan, SH,Zang, ZY,et al. Single cell imaging with near-field terahertz scanning microscopy[J]. CELL PROLIFERATION,2020,53(4):-.
APA	Li, ZX.,Yan, SH.,Zang, ZY.,Geng, GS.,Yang, ZB.,...&Wang, HB.(2020).Single cell imaging with near-field terahertz scanning microscopy.CELL PROLIFERATION,53(4),-.
MLA	Li, ZX,et al."Single cell imaging with near-field terahertz scanning microscopy".CELL PROLIFERATION 53.4(2020):-.