PolyA-based DNA bonds with programmable bond length and bond energy

doi:10.1038/s41427-020-0231-x

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	PolyA-based DNA bonds with programmable bond length and bond energy
	Chen, XL ; Liu, XG ; Yao, GB ; Li, Q ; Liu, RD ; Wu, HJ ; Lv, YN ; Fan, CH ; Wang, LH ; Li, J
刊名	NPG ASIA MATERIALS
	2020
卷号	12 期号:1 页码:-
关键词	NUCLEOSOME CORE PARTICLE NANOPARTICLE SUPERLATTICES CRYSTAL-STRUCTURE NANOSTRUCTURES FUNCTIONALIZATION OLIGONUCLEOTIDE ASSEMBLIES ORDER
ISSN号	1884-4049
DOI	10.1038/s41427-020-0231-x
文献子类	期刊论文
英文摘要	DNA-functionalized Au nanoparticles (AuNPs) have been intensively exploited as programmable atom equivalents (PAEs) for the self-assembly of molecule-like structures. However, it remains challenging to build hierarchical PAE assemblies via discrete DNA bonds at different levels. Here, we report a strategy to program DNA bond length and bond energy on PAEs using DNA encoders carrying consecutive adenines (polyA). On AuNPs, we built three types of DNA motifs with different topologic configurations, which can form bonds for PAE self-assembly. By small-angle X-ray scattering (SAXS) analysis, we found that the bond length and flexibility between the coupled PAEs can be tuned by programming the bond structure. We also found that these bonds show different bond energies and thus differ, depending on their topologic configuration, leading to different PAE assembly efficiencies. We demonstrated that the bonds at different levels can be arranged in different directions on one nanoparticle, leading to asymmetric PAEs that allow ionic strength-controlled hierarchical assembly of multiparticle structures. This programmable bonding system may provide a new route for building complex plasmonic superstructures.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/33068]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Div Phys Biol, CAS Key Lab Interfacial Phys & Technol, Shanghai Inst Appl Phys,Univ Chinese Acad Sci, Shanghai 201800, Peoples R China 2.Shanghai Jiao Tong Univ, Frontiers Sci Ctr Transformat Mol, Sch Chem & Chem Engn, Inst Mol Med,Renji Hosp,Sch Med, Shanghai 200240, Peoples R China 3.Chinese Acad Sci, Shanghai Adv Res Inst, Zhangjiang Lab, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Chen, XL,Liu, XG,Yao, GB,et al. PolyA-based DNA bonds with programmable bond length and bond energy[J]. NPG ASIA MATERIALS,2020,12(1):-.
APA	Chen, XL.,Liu, XG.,Yao, GB.,Li, Q.,Liu, RD.,...&Li, J.(2020).PolyA-based DNA bonds with programmable bond length and bond energy.NPG ASIA MATERIALS,12(1),-.
MLA	Chen, XL,et al."PolyA-based DNA bonds with programmable bond length and bond energy".NPG ASIA MATERIALS 12.1(2020):-.