A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA

	A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA
	Kim, Ha Na 1; Lee, Eun-Hae 2,3; Xu, Zhaochao 1,4; Kim, Hee-Eun 2,3; Lee, Hee-Seung 5; Lee, Joon-Hwa 2,3; Yoon, Juyoung 1,6
刊名	biomaterials
	2012-03-01
卷号	33 期号:7 页码:2282-2288
关键词	G-quadruplex NMR Fluorescent sensor Imidazolium Pyrene Excimer emission
ISSN号	0142-9612
通讯作者	wenjunwu ; davidrspring
产权排序	3,3
英文摘要	g-quadruplexes, formed of four stranded guanine bases stabilized by monovalent cations, serve important role in cancer cell growth and control gene expression in telomere. since there are various types of quadruplex structures, rapid and simple screening methods with high selectivity, sensitivity and nontoxicity are required for understanding about the biological roles of quadruplex dna as well as in designing therapeutics. herein, we report a pyrene-imidazolium derivative, jy-1, which can with high selectivity recognize g-quadruplex using fluorescence and nmr spectroscopy. this is the first example based on the imidazolium derivative, which can detect the g-quadruplex directly to utilize the excimer/monomer emission change in pyrene fluorophore. the selectivity of strong binding to a specific sequence can allow for quadruplex sensing and the detection method presented here is very simple, using fluorescence and nmr study. also, the groove binding characteristic of jy-1 to the g-quadruplex has a relatively low nonspecific toxicity and the structure-specific differences in fluorescent character between dna duplex and g-quadruplex may offer more discovery and application in biological study. (c) 2011 elsevier ltd. all rights reserved.
学科主题	物理化学
WOS标题词	science & technology ; technology
类目[WOS]	engineering, biomedical ; materials science, biomaterials
研究领域[WOS]	engineering ; materials science
关键词[WOS]	colorimetric chemosensors ; fluorescent-probe ; recent progress ; potassium-ion ; binding ; transition ; parallel ; fluoride ; receptor ; binders
收录类别	SCI
语种	英语
WOS记录号	WOS:000300473900035
公开日期	2013-10-11
内容类型	期刊论文
源URL	[http://159.226.238.44/handle/321008/117860]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	1.Ewha Womans Univ, Dept Chem & Nano Sci, Seoul 120750, South Korea 2.Gyeongsang Natl Univ, Dept Chem, Jinju 660701, Gyeongnam, South Korea 3.Gyeongsang Natl Univ, RINS, Jinju 660701, Gyeongnam, South Korea 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 5.Korea Adv Inst Sci & Technol, Dept Chem, Mol Level Interface Res Ctr, Taejon 305701, South Korea 6.Ewha Womans Univ, Dept Bioinspired Sci, Seoul 120750, South Korea
推荐引用方式 GB/T 7714	Kim, Ha Na,Lee, Eun-Hae,Xu, Zhaochao,et al. A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA[J]. biomaterials,2012,33(7):2282-2288.
APA	Kim, Ha Na.,Lee, Eun-Hae.,Xu, Zhaochao.,Kim, Hee-Eun.,Lee, Hee-Seung.,...&Yoon, Juyoung.(2012).A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA.biomaterials,33(7),2282-2288.
MLA	Kim, Ha Na,et al."A pyrene-imidazolium derivative that selectively Recognizes G-Quadruplex DNA".biomaterials 33.7(2012):2282-2288.