Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease

doi:10.1523/JNEUROSCI.0242-21.2021

	Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease
	Liu, Wenyue 3,4; Wang, Changpeng 5; He, Tingting 5; Su, Minghong 1,4; Lu, Yuan 3; Zhang, Guanyu 1,4; Munte, Thomas F.6; Jin, Lirong 5; Ye, Zheng 2,3
刊名	JOURNAL OF NEUROSCIENCE
	2021-07-21
卷号	41 期号:29 页码:6304-6313
关键词	basal ganglia functional MRI neuromelanin-sensitive MRI Parkinson's disease sequential working memory substantia nigra
ISSN号	0270-6474
DOI	10.1523/JNEUROSCI.0242-21.2021
通讯作者	Jin, Lirong(jinlr99@163.com) ; Ye, Zheng(yez@ion.ac.cn)
英文摘要	Maintaining and manipulating sequences online is essential for daily activities such as scheduling a day. In Parkinson's disease (PD), sequential working memory deficits have been associated with altered regional activation and functional connectivity in the basal ganglia. This study demonstrates that the substantia nigra (SN) integrity correlated with basal ganglia function and sequencing perform-ance in 29 patients with PD (17 women) and 29 healthy controls (HCs; 18 women). In neuromelanin-sensitive structural magnetic resonance imaging (MRI), PD patients showed smaller SNs than HCs. In a digitordering task with functional MRI (fMRI), partici-pants either recalled sequential digits in the original order (pure recall) or rearranged the digits and recalled the new sequence (reorder and recall). PD patients performed less accurately than HCs, accompanied by the caudate and pallidal hypoactivation, subthalamic hyperactivation, and weakened functional connectivity between the bilateral SN and all three basal ganglia regions. PD patients with larger SNs tended to exhibit smaller ordering-related accuracy costs (reorder and recall vs pure recall). This effect was fully mediated by the ordering-related caudate activation. Unlike HCs, the ordering-related accuracy cost correlated with the ordering-related caudate activation but not subthalamic activation in PD patients. Moreover, the ordering-related caudate activation correlated with the SN area but not with the daily dose of D-2/3 receptor agonists. In PD patients, the daily dose of D-2/3 receptor agonists correlated with the ordering-related subthalamic activation, which was not related to the accuracy cost. The findings suggest that damage to the SN may lead to sequential working memory deficits in PD patients, mediated by basal ganglia dysfunction.
收录类别	SCI
资助项目	National Natural Science Foundation of China[31961133025] ; National Natural Science Foundation of China[31771216] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX05] ; Shanghai Municipal Science and Technology Commission[2018ZR1406500]
WOS关键词	MPTP-TREATED MONKEYS ; DOPAMINERGIC INNERVATION ; SUBTHALAMIC NUCLEUS ; NEURONAL-ACTIVITY ; NORMAL-STATE ; NEUROMELANIN ; RELEVANCE ; VALIDITY ; NETWORK ; LESION
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SOC NEUROSCIENCE
WOS记录号	WOS:000684595300013
资助机构	National Natural Science Foundation of China ; Shanghai Municipal Science and Technology Major Project ; Shanghai Municipal Science and Technology Commission
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40131]
专题	心理研究所_健康与遗传心理学研究室
通讯作者	Jin, Lirong; Ye, Zheng
作者单位	1.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 2.Shanghai Ctr Brain Sci & Brain Inspired Intellige, Shanghai 201210, Peoples R China 3.Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligence Technol, Inst Neurosci, Key Lab Primate Neurobiol, Shanghai 200031, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200032, Peoples R China 6.Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany
推荐引用方式 GB/T 7714	Liu, Wenyue,Wang, Changpeng,He, Tingting,et al. Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease[J]. JOURNAL OF NEUROSCIENCE,2021,41(29):6304-6313.
APA	Liu, Wenyue.,Wang, Changpeng.,He, Tingting.,Su, Minghong.,Lu, Yuan.,...&Ye, Zheng.(2021).Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease.JOURNAL OF NEUROSCIENCE,41(29),6304-6313.
MLA	Liu, Wenyue,et al."Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease".JOURNAL OF NEUROSCIENCE 41.29(2021):6304-6313.