The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia

doi:10.3389/fpsyt.2021.704045

CORC > 心理研究所 > 中国科学院心理研究所 > 中国科学院心理健康重点实验室

	The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia
	Cao, Haiyan 1; Zhou, Yongjie 4; Li, Tao 1; Yao, Cong 1; Yang, Weiliang 1; Kong, Siying 1; Wang, Yanyan 1; Yu, Baoping 1; Jiao, Qingyan 1; Sun, Yun 1
刊名	FRONTIERS IN PSYCHIATRY
	2021-08-16
卷号	12 页码:11
关键词	schizophrenia antipsychotics QTc prolongation Chinese prevalence risk factor clinical correlates
ISSN号	1664-0640
DOI	10.3389/fpsyt.2021.704045
通讯作者	Zhang, Xiangyang(zhangxy@psych.ac.cn) ; Li, Jie(jieli@tjmhc.com)
英文摘要	Background: The QTc interval may be significantly prolonged in schizophrenia patients taking antipsychotics. Few studies have addressed QTc prolongation (QTP) in Chinese patients. & nbsp; Objectives: This study was designed to evaluate the prevalence of QTP and its clinical correlates in Chinese hospitalized patients with chronic schizophrenia. & nbsp; Methods: A total of 436 inpatients and 291 normal controls matched with age and sex were included. QTc prolongation was defined as 2 standard deviations (SD) above the mean value of normal controls. Positive and Negative Syndrome Scale (PANSS) and its five-factor model were used to evaluate psychopathological symptoms. & nbsp; Results: QTc interval was significantly longer in patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. More women than men displayed QTP. Compared with patients without QTP, the patients with QTP had significantly higher concrete/disorganized subscore, lower low density lipoprotein (LDL) and lower total protein (TP). Furthermore, binary logistic regression analysis showed that higher number of hospitalizations, higher concrete/disorganized subscore and lower LDL were risk factors for QTP. Correlation analysis indicated significant association between QTc interval and the following variables: sex, age, duration of illness, the number of hospitalizations, PANSS total score, fasting blood glucose (FPG). Finally, a multiple regression analysis showed that older age, antipsychotic polypharmacy, higher PANSS total score, and lower LDL were risk factors for QTP. Among them, LDL seemed to be a protective factor for QTP. & nbsp; Conclusions: QTc interval was longer in schizophrenia patients than in normal controls. The prevalence of QTP is 8.26% in Chinese hospitalized patients with chronic schizophrenia. Some clinical characteristics were risk factors for QTP. And LDL seemed to be a protective factor for QTP.
收录类别	SCI
资助项目	National Key R&D Program of China by Ministry of Science and Technology of China[2016YFC1306800] ; Tianjin Key Project for Chronic Diseases Prevention by Tianjin Municipal Science and Technology Bureau[2017ZXMFSY00070] ; Tianjin Key Discipline for Psychiatry
WOS关键词	NEGATIVE SYNDROME SCALE ; INTERVAL PROLONGATION ; ANTIPSYCHOTIC-DRUGS ; 5-FACTOR MODEL ; DE-POINTES ; KCNH2 ; GENE ; ELECTROCARDIOGRAM ; REPOLARIZATION ; ADOLESCENTS
WOS研究方向	Psychiatry
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000693099000001
资助机构	National Key R&D Program of China by Ministry of Science and Technology of China ; Tianjin Key Project for Chronic Diseases Prevention by Tianjin Municipal Science and Technology Bureau ; Tianjin Key Discipline for Psychiatry
内容类型	期刊论文
源URL	[http://ir.psych.ac.cn/handle/311026/40199]
专题	心理研究所_中国科学院心理健康重点实验室
通讯作者	Zhang, Xiangyang; Li, Jie
作者单位	1.Tianjin Med Univ, Inst Mental Hlth, Tianjin Anding Hosp, Tianjin, Peoples R China 2.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China 3.Jining Psychiat Hosp, Dept Psychiat, Jining, Peoples R China 4.Shenzhen Kangning Hosp, Dept Psychiat Rehabil, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Cao, Haiyan,Zhou, Yongjie,Li, Tao,et al. The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia[J]. FRONTIERS IN PSYCHIATRY,2021,12:11.
APA	Cao, Haiyan.,Zhou, Yongjie.,Li, Tao.,Yao, Cong.,Yang, Weiliang.,...&Li, Jie.(2021).The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia.FRONTIERS IN PSYCHIATRY,12,11.
MLA	Cao, Haiyan,et al."The Prevalence, Risk Factors and Clinical Correlates of QTc Prolongation in Chinese Hospitalized Patients With Chronic Schizophrenia".FRONTIERS IN PSYCHIATRY 12(2021):11.