A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf

doi:10.1080/14786419.2019.1628749

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf
	Laura, Gertrude Foudjo Melacheu 4; Njoya, Emmanuel Mfotie 2,3; Jouda, Jean-Bosco 4; Kweka, Brussine Nadege Wakeu 4; Mbazoa, Celine Djama 4; Wang, Fei 3; Seguin, Elisabeth 1; Wandji, Jean 4
刊名	NATURAL PRODUCT RESEARCH
	2019
页码	1628749
关键词	Tabernaemontana inconspicua indole alkaloids cytotoxic activity
ISSN号	1478-6419
DOI	10.1080/14786419.2019.1628749
产权排序	2
文献子类	Article; Early Access
英文摘要	One new indole alkaloid derivative, 5,6-dioxo-11-hydroxy voacangine (1) together with four known compounds (2-5), were isolated from the fruits of Tabernaemontana contorta Stapf (Apocynaceae). Their structures were determined using 1D and 2D NMR, HRESI-MS, and a comparison with the literature. The new compound was found to be cytotoxic on human breast cancer MDA-MB 231 cells with IC50 values of 3.35 mu M and 2.19 mu M after 24 and 48 hours, respectively. [GRAPHICS] .
学科主题	Chemistry & Analysis
URL标识	查看原文
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000478314300001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/31064]
专题	国家天然药物工程技术研究中心_天然产物研究
通讯作者	Mbazoa, Celine Djama
作者单位	1.Univ Rouen, Fac Med & Pharm, Lab Pharmacogniosie, Rouen 1, France 2.Univ Yaounde I, Fac Sci, Dept Biochem, Yaounde, Cameroon; 3.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China; 4.Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon;
推荐引用方式 GB/T 7714	Laura, Gertrude Foudjo Melacheu,Njoya, Emmanuel Mfotie,Jouda, Jean-Bosco,et al. A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf[J]. NATURAL PRODUCT RESEARCH,2019:1628749.
APA	Laura, Gertrude Foudjo Melacheu.,Njoya, Emmanuel Mfotie.,Jouda, Jean-Bosco.,Kweka, Brussine Nadege Wakeu.,Mbazoa, Celine Djama.,...&Wandji, Jean.(2019).A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf.NATURAL PRODUCT RESEARCH,1628749.
MLA	Laura, Gertrude Foudjo Melacheu,et al."A new cytotoxic indole alkaloid from Tabernaemontana inconspicua stapf".NATURAL PRODUCT RESEARCH (2019):1628749.