Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging

doi:10.1039/c9cc06734e

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging
	Bai, Ping 2,3,4; Wey, Hsiao-Ying 3; Patnaik, Debasis 1; Lu, Xiaoxia 4; Lan, Yu 3; Rokka, Johanna 3; Stephanie, Fiedler 3; Haggarty, Stephen J.1; Wang, Changning 3
刊名	CHEMICAL COMMUNICATIONS
	2019
卷号	55 期号:86 页码:12932-12935
ISSN号	1359-7345
DOI	10.1039/c9cc06734e
产权排序	1
文献子类	Article
英文摘要	Here, we report the development of novel PET radiotracer ([C-11]CW22) of BET proteins. In vivo imaging results in rodents and nonhuman primates (NHP) demonstrate that [C-11]CW22 has excellent brain uptake, good specificity, good selectivity, suitable metabolism, appropriate kinetics and distribution in the brain. Our studies demonstrated that [C-11]CW22 exhibits ideal properties as a PET imaging probe of BET proteins for further validation.
学科主题	Chemistry
URL标识	查看原文
WOS关键词	INHIBITOR OTX015 ; OPTIMIZATION ; DISCOVERY ; REGULATOR ; BRD4 ; PET
WOS研究方向	Chemistry
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000492378600006
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30947]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Ctr Genom Med,Chem Neurobiol Lab, Boston, MA 02114 USA 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA; 4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Sichuan, Peoples R China;
推荐引用方式 GB/T 7714	Bai, Ping,Wey, Hsiao-Ying,Patnaik, Debasis,et al. Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging[J]. CHEMICAL COMMUNICATIONS,2019,55(86):12932-12935.
APA	Bai, Ping.,Wey, Hsiao-Ying.,Patnaik, Debasis.,Lu, Xiaoxia.,Lan, Yu.,...&Wang, Changning.(2019).Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging.CHEMICAL COMMUNICATIONS,55(86),12932-12935.
MLA	Bai, Ping,et al."Positron emission tomography probes targeting bromodomain and extra-terminal (BET) domains to enable in vivo neuroepigenetic imaging".CHEMICAL COMMUNICATIONS 55.86(2019):12932-12935.