Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus

doi:10.1080/13510002.2018.1540675

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 国家天然药物工程技术研究中心 > 天然产物研究

	Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus
	Ebokaiwe, Azubuike P.1,5; Ijomone, Omamuyovwi M.4; Osawe, Sharon O.3; Chukwu, Chukwuma J.5; Ejike, Chukwunonso E. C. C.2; Zhang, Guolin 1; Wang, Fei 1
刊名	REDOX REPORT
	2018
卷号	23 期号:1 页码:194-205
关键词	Loranthus micranthus spermiogram diabetes oxidative stress apoptosis steroid hormones male rats
ISSN号	1351-0002
DOI	10.1080/13510002.2018.1540675
产权排序	5
文献子类	Article
英文摘要	Objectives: Loranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ). Methods: Induction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide or L. micranthus (100 mg/kg or 200 mg/kg) and monitored for 14 days. Clinical observations, hormonal profile, oxidative stress parameters, glucose metabolism enzymes, histopathological examination, apoptotic marker immunoreactivity and western blotting in testes and sperm parameters were evaluated to examine effects of L. micranthus on STZ-diabetic rats. Results: L. micranthus treatment significantly reduced the blood glucose level (45.9% and 84.7% on the 7th and 14th post-treatment days, respectively); increased antioxidant status, improved microarchitecture of testes, reduced lipid peroxidation and increased BCI-2 protein expression in diabetic rats relative to control. Furthermore, treatment with L. micranthus increased steroidogenic enzymes activities, levels of steroid hormones and improved sperm quality, relative to control. Conclusion: The anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes.
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WOS关键词	HIGH-ENERGY DIETS ; ANTIOXIDANT ACTIVITY ; INSULIN-RESISTANCE ; GLUCOSE ; CALCIFICATION ; CAPACITATION ; TESTOSTERONE ; INFLAMMATION ; POLYPHENOLS ; GLUTATHIONE
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000451191400001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30367]
专题	国家天然药物工程技术研究中心_天然产物研究
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu, Sichuan, Peoples R China 2.Fed Univ Ndufu Alike Ikwo, Coll Med, Dept Med Biochem, Ikwo, Nigeria; 3.KolaDaisi Univ, Fac Appl Sci, Dept Biochem, Ibadan, Nigeria; 4.Fed Univ Technol Akure, Sch Hlth & Hlth Technol, Dept Anat, Akure, Nigeria; 5.Fed Univ Ndufu Alike Ikwo, Dept Chem Biochem & Mol Biol, Ikwo, Nigeria;
推荐引用方式 GB/T 7714	Ebokaiwe, Azubuike P.,Ijomone, Omamuyovwi M.,Osawe, Sharon O.,et al. Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus[J]. REDOX REPORT,2018,23(1):194-205.
APA	Ebokaiwe, Azubuike P..,Ijomone, Omamuyovwi M..,Osawe, Sharon O..,Chukwu, Chukwuma J..,Ejike, Chukwunonso E. C. C..,...&Wang, Fei.(2018).Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus.REDOX REPORT,23(1),194-205.
MLA	Ebokaiwe, Azubuike P.,et al."Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role of Loranthus micranthus".REDOX REPORT 23.1(2018):194-205.