Mechanisms by Which Small RNAs Affect Bacterial Activity

doi:10.1177/0022034519876898

CORC > 成都生物研究所 > 中国科学院成都生物研究所 > 食品安全与环境治理领域 > 农业生物技术研究

	Mechanisms by Which Small RNAs Affect Bacterial Activity
	Lei, L.2; Yang, Y.2,3; Wu, S.1; Ma, X.4; Mao, M.2,5; Hu, T.2
刊名	JOURNAL OF DENTAL RESEARCH
	2019
卷号	98 期号:12 页码:1315-1323-UNSP 0022034519876898
关键词	biofilm dental plaque noncoding RNA pathogenicity polysaccharides regulation
ISSN号	0022-0345
DOI	10.1177/0022034519876898
产权排序	4
文献子类	Review
英文摘要	The oral cavity contains a distinct habitat that supports diverse bacterial flora. Recent observations have provided additional evidence that sRNAs are key regulators of bacterial physiology and pathogenesis. These sRNAs have been divided into 5 functional groups: cis-encoded RNAs, trans-encoded RNAs, RNA regulators of protein activity, bacterial CRISPR (clustered regularly interspaced short palindromic repeat) RNAs, and a novel category of miRNA-size small RNAs (msRNAs). In this review, we discuss a critical group of key commensal and opportunistic oral pathogens. In general, supragingival bacterial sRNAs function synergistically to fine-tune the regulation of cellular processes and stress responses in adaptation to environmental changes. Particularly in the cariogenic bacteria Streptococcus mutans, both the antisense vicR RNA and msRNA1657 can impede the metabolism of bacterial exopolysaccharides, prevent biofilm formation, and suppress its cariogenicity. In Enterococcus faecalis, selected sRNAs control the expression of proteins involved in diverse cellular processes and stress responses. In subgingival plaques, sRNAs from periodontal pathogens can function as novel bacterial signaling molecules that mediate bacterial-human interactions in periodontal homeostasis. In Porphyromonas gingivalis, the expression profiles of putative sRNA101 and sRNA42 were found to respond to hemin availability after hemin starvation. Regarding Aggregatibacter actinomycetemcomitans (previously Actinobacillus actinomycetemcomitans), a major periodontal pathogen associated with aggressive periodontitis, the predicted sRNAs interact with several virulence genes, including those encoding leukotoxin and cytolethal distending toxin. Furthermore, in clinical isolates, these associated RNAs could be explored not only as potential biomarkers for oral disease monitoring but also as alternative types of regulators for drug design. Thus, this emerging subspecialty of bacterial regulatory RNAs could reshape our understanding of bacterial gene regulation from their key roles of endogenous regulatory RNAs to their activities in pathologic processes.
学科主题	Dentistry/oral Surgery & Medicine
URL标识	查看原文
WOS关键词	OUTER-MEMBRANE VESICLES ; STREPTOCOCCUS-MUTANS ; PORPHYROMONAS-GINGIVALIS ; ORAL MICROBIOME ; MICRORNA-SIZE ; REGULATORY RNAS ; EXPRESSION ; HFQ ; SUSCEPTIBILITY ; PROXIMITY
WOS研究方向	Dentistry, Oral Surgery & Medicine
语种	英语
出版者	SAGE PUBLICATIONS INC
WOS记录号	WOS:000491687200001
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30491]
专题	环境治理与食品安全领域_农业生物技术研究
作者单位	1.Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China; 2.Sichuan Univ, West China Hosp Stomatol, Dept Prevent Dent, State Key Lab Oral Dis, 14,3rd Sect,Renmin South Rd, Chengdu 610041, Sichuan, Peoples R China; 3.Cent S Univ, State Key Lab Powder Met, Changsha, Hunan, Peoples R China; 4.Chinese Acad Sci, Chengdu Inst Biol, Chengdu, Sichuan, Peoples R China; 5.Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, 639 Zhizao Ju Rd, Shanghai 200240, Peoples R China
推荐引用方式 GB/T 7714	Lei, L.,Yang, Y.,Wu, S.,et al. Mechanisms by Which Small RNAs Affect Bacterial Activity[J]. JOURNAL OF DENTAL RESEARCH,2019,98(12):1315-1323-UNSP 0022034519876898.
APA	Lei, L.,Yang, Y.,Wu, S.,Ma, X.,Mao, M.,&Hu, T..(2019).Mechanisms by Which Small RNAs Affect Bacterial Activity.JOURNAL OF DENTAL RESEARCH,98(12),1315-1323-UNSP 0022034519876898.
MLA	Lei, L.,et al."Mechanisms by Which Small RNAs Affect Bacterial Activity".JOURNAL OF DENTAL RESEARCH 98.12(2019):1315-1323-UNSP 0022034519876898.