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	Xylastriasan A, a new cytochalasan from the fungus Xylaria striata
	Lei, Chuan-Wen2; Yang, Zhi-Qin2; Zeng, Yan-Ping2; Zhou, Yun2; Huang, Yi2; He, Xin-Sheng2; Li, Guo-You1; Yuan, Xiao-Hong2
刊名	NATURAL PRODUCT RESEARCH
	2018
卷号	32期号:1页码:7-13
关键词	Xylaria striata cytochalasan ergosterol cytotoxic hypnotic activity
ISSN号	1478-6419
DOI	10.1080/14786419.2017.1324959
产权排序	2
文献子类	Article
英文摘要	Xylastriasan A (1), a new cytochalasan alkaloid with a rare 5/6/6/5/6 pentacyclic skeleton, and ergosterol (2) were isolated from the ethanol extract of fruiting bodies of the fungus Xylaria striata. Their structures were determined by analysis of their spectroscopic data. Compound 1 exhibited weak cytotoxic activity against HEPG2, B16 and A549 cell lines with IC50 values of 93.61, 85.61 and 91.58 mu M, respectively. Ergosterol (2) potentiated pentobarbital-induced sleep by not only increasing the number of falling asleep and prolonging sleeping time but also reducing sleep latency at a dosage of 5 mg/kg. [GRAPHICS] .
URL标识	查看原文
WOS关键词	CYTOTOXIC CONSTITUENTS ; ENDOPHYTIC FUNGUS ; SPICARIA-ELEGANS ; MICE
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	TAYLOR & FRANCIS LTD
WOS记录号	WOS:000417625600002
内容类型	期刊论文
源URL	[http://210.75.237.14/handle/351003/30364]
专题	环境治理与食品安全领域_应用与环境微生物研究
作者单位	1.Chinese Acad Sci, Chengdu Inst Biol, Key Lab Environm & Appl Microbiol, Chengdu, Sichuan, Peoples R China 2.Southwest Univ Sci & Technol, Sch Life Sci & Engn, Mianyang, Peoples R China;
推荐引用方式 GB/T 7714	Lei, Chuan-Wen,Yang, Zhi-Qin,Zeng, Yan-Ping,et al. Xylastriasan A, a new cytochalasan from the fungus Xylaria striata[J]. NATURAL PRODUCT RESEARCH,2018,32(1):7-13.
APA	Lei, Chuan-Wen.,Yang, Zhi-Qin.,Zeng, Yan-Ping.,Zhou, Yun.,Huang, Yi.,...&Yuan, Xiao-Hong.(2018).Xylastriasan A, a new cytochalasan from the fungus Xylaria striata.NATURAL PRODUCT RESEARCH,32(1),7-13.
MLA	Lei, Chuan-Wen,et al."Xylastriasan A, a new cytochalasan from the fungus Xylaria striata".NATURAL PRODUCT RESEARCH 32.1(2018):7-13.

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