African lungfish genome sheds light on the vertebrate water-to-land transition

doi:10.1016/j.cell.2021.01.047

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	African lungfish genome sheds light on the vertebrate water-to-land transition
	Wang, Kun 18; Wang, Jun 16,17; Zhu, Chenglong 15,18; Yang, Liandong 14; Ren, Yandong 15,18; Ruan, Jue 13; Fan, Guangyi 11,12; Hu, Jiang 10; Xu, Wenjie 18; Bi, Xupeng 11
刊名	CELL
	2021-03-04
卷号	184 期号:5 页码:1-15
ISSN号	0092-8674
DOI	10.1016/j.cell.2021.01.047
英文摘要	Lungfishes are the closest extant relatives of tetrapods and preserve ancestral traits linked with the water-to-land transition. However, their huge genome sizes have hindered understanding of this key transition in evolution. Here, we report a 40-Gb chromosome-level assembly of the African lungfish (Protopterus annectens) genome, which is the largest genome assembly ever reported and has a contig and chromosome N50 of 1.60 Mb and 2.81 Gb, respectively. The large size of the lungfish genome is due mainly to retrotransposons. Genes with ultra-long length show similar expression levels to other genes, indicating that lungfishes have evolved high transcription efficacy to keep gene expression balanced. Together with transcriptomeand experimental data, we identified potential genes and regulatory elements related to such terrestrial adaptation traits as pulmonary surfactant, anxiolytic ability, pentadactyl limbs, and pharyngeal remodeling. Our results provide insights and key resources for understanding the evolutionary pathway leading from fishes to humans.
资助项目	Fish10K project ; Strategic Priority Research Program of CAS[XDB13000000] ; 1000 Talent Project of Shaanxi Province ; Research Funds for Interdisciplinary Subject, NWPU[19SH030408] ; State Key Laboratory of Freshwater Ecology and Biotechnology ; Youth Innovation Promotion Association of the CAS ; NSFC of China[41876179] ; NSFC of China[31972866] ; Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2018) ; National Key Research and Development Program of China[2018YFD0900604] ; Villum Foundation[25900] ; Frasergen Bioinformatics Co., Ltd.
WOS研究方向	Biochemistry & Molecular Biology ; Cell Biology
语种	英语
出版者	CELL PRESS
WOS记录号	WOS:000629635700021
内容类型	期刊论文
源URL	[http://119.78.100.205/handle/311034/18564]
专题	古脊椎动物与古人类研究所_图书馆1
通讯作者	Zhao, Wenming; Qiu, Qiang; He, Shunping; Wang, Wen
作者单位	1.Northwestern Polytech Univ, Xian 710072, Peoples R China 2.Chinese Acad Sci, Inst Deep Sea Sci & Engn, Sanya 572000, Peoples R China 3.Univ Copenhagen, Villum Ctr Biodivers Genom, Dept Biol, Sect Ecol & Evolut, Copenhagen, Denmark 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China 5.Southwest Univ, Sch Life Sci, Key Lab Freshwater Fish Reprod & Dev, Chongqing 400715, Peoples R China 6.China Natl Ctr Bioinformat, Beijing 100101, Peoples R China 7.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China 8.Northwest A&F Univ, Coll Vet Med, Dept Clin Vet Med, Key Lab Anim Biotechnol,Minist Agr, Yangling 712100, Shaanxi, Peoples R China 9.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Beijing 100044, Peoples R China 10.Grand Biosci, Beijing 102200, Peoples R China
推荐引用方式 GB/T 7714	Wang, Kun,Wang, Jun,Zhu, Chenglong,et al. African lungfish genome sheds light on the vertebrate water-to-land transition[J]. CELL,2021,184(5):1-15.
APA	Wang, Kun.,Wang, Jun.,Zhu, Chenglong.,Yang, Liandong.,Ren, Yandong.,...&Wang, Wen.(2021).African lungfish genome sheds light on the vertebrate water-to-land transition.CELL,184(5),1-15.
MLA	Wang, Kun,et al."African lungfish genome sheds light on the vertebrate water-to-land transition".CELL 184.5(2021):1-15.