Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe

doi:10.1021/acs.analchem.1c03109

	Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe
	Li, Dandan 1,2; Tian, Xiaohe 1,2; Liu, Zhengjie 1,2,3; Liu, Jiejie 1,2; Han, Guangmei 1,2,3; Liu, Bianhua 4; Zhao, Jun 4; Zhang, Ruilong 1,2,3; Tian, Yupeng 1,2,3; Zhang, Zhongping 1,2,3
刊名	ANALYTICAL CHEMISTRY
	2021-10-12
卷号	93
ISSN号	0003-2700
DOI	10.1021/acs.analchem.1c03109
通讯作者	Zhang, Ruilong(zrl@ahu.edu.cn)
英文摘要	Understanding signaling molecules in regulating organelles dynamics and programmed cell death is critical for embryo development but chameleon-like probe is also challenging because current imaging probes are incapable of simultaneously imaging the signaling molecules and the intracellular organelles they interact with. Here, we report a chemically and environmentally dual-responsive imaging probe that can react with gasotransmitters and label cell nuclei in distinctive fluorescent colors, similar to the adaptive coloration of chameleons. Using this intracellular chameleon-like probe in three-dimensional (3D) super-resolution dynamic imaging of live cells, we discovered SO2 as a critical upstream signaling molecule that activates nucleophagy in programmed cell death. An elevated level of SO2 prompts kiss fusion between the lysosomal and nuclear membranes and nucleus shrinkage and rupture. Significantly, we revealed that the gasotransmitter SO2 is majorly generated in the yolk, induces autophagy there at the initial stage of embryo development, and is highly related to the development of the auditory nervous system.
资助项目	National Natural Science Foundation of China[21775001] ; National Natural Science Foundation of China[21871003] ; National Natural Science Foundation of China[21974001] ; National Natural Science Foundation of China[21976183] ; National Natural Science Foundation of China[22074001] ; National Natural Science Foundation of China[22171001] ; Anhui Provincial Natural Science Foundation of China[1808085MB32] ; Anhui Provincial Natural Science Foundation of China[2108085MB49] ; Science and Technology Service Network Initiative of the Chinese Academy of China[KFJ-STS-ZDTP-080]
WOS关键词	PROGRAMMED CELL-DEATH ; LIVING CELLS ; COMPLEX
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000708550500032
资助机构	National Natural Science Foundation of China ; Anhui Provincial Natural Science Foundation of China ; Science and Technology Service Network Initiative of the Chinese Academy of China
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125603]
专题	中国科学院合肥物质科学研究院
通讯作者	Zhang, Ruilong
作者单位	1.Anhui Univ, Sch Chem & Chem Engn, Informat Mat & Intelligent Sensing Lab Anhui Prov, Hefei 230601, Peoples R China 2.Anhui Univ, Inst Phys Sci & Informat Technol, Hefei 230601, Peoples R China 3.Anhui Univ, Key Lab Struct & Funct Regulat Hybrid Mat, Minist Educ, Hefei 230601, Anhui, Peoples R China 4.Chinese Acad Sci, Inst Solid State Phys, Key Lab Photovolta & Energy Conservat Mat, HFIPS, Hefei 230031, Peoples R China
推荐引用方式 GB/T 7714	Li, Dandan,Tian, Xiaohe,Liu, Zhengjie,et al. Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe[J]. ANALYTICAL CHEMISTRY,2021,93.
APA	Li, Dandan.,Tian, Xiaohe.,Liu, Zhengjie.,Liu, Jiejie.,Han, Guangmei.,...&Zhang, Zhongping.(2021).Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe.ANALYTICAL CHEMISTRY,93.
MLA	Li, Dandan,et al."Revealing Sulfur Dioxide Regulation to Nucleophagy in Embryo Development by an Adaptive Coloration Probe".ANALYTICAL CHEMISTRY 93(2021).