Tigecycline-Induced Tooth Discoloration in Children Younger than Eight Years

doi:10.1128/AAC.00854-21

	Tigecycline-Induced Tooth Discoloration in Children Younger than Eight Years
	Zhu, Zhengyi 1; Yu, Qi 2; Qi, Ganggang 2; Yang, Jufei 1; Ni, Yinghua 1; Ruan, Wenhua 3; Fang, Luo 4
刊名	ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
	2021-09-01
卷号	65
关键词	tigecycline adverse event children tooth discoloration
ISSN号	0066-4804
DOI	10.1128/AAC.00854-21
通讯作者	Ruan, Wenhua(zyeykqk@zju.edu.cn) ; Fang, Luo(fangluo@zjcc.org.cn)
英文摘要	Tetracycline may cause tooth discoloration when used in young children during tooth development. Whether tigecycline, a tetracycline derivative, has either a similar adverse event or not remains unclear. We assessed the discoloration of the permanent teeth of patients <8 years old after tigecycline exposure. These patients were identified through a retrospective chart review in a Chinese children's hospital. Those who had at least one erupted permanent tooth after tigecycline exposure were interviewed, examined, and photographed by an experienced pediatric dentist and independently assessed by another senior dentist to detect tetracycline-like tooth discoloration. We identified 101 patients who were exposed to tigecycline, 12 of whom were included. The mean daily dose of tigecycline was 2.3 mg/kg of body weight (standard deviation, 0.6), and the median duration was 125 days (interquartile range (IQR], 8.0 to 19.3). The median age of exposure was 5.2 years (IQR, 45 to 7.4), and the median age of dental examination was 9.1 years (IQR, 9.0 to 10.3). Two patients (16.7%) developed yellow discoloration: a girl having yellow discoloration with white-to-yellow opacities in the upper lateral incisors and lower incisors and a boy with a suspicious buccal yellow discoloration and enamel dysplasia in the second molars. The incidence and extent of tigecycline-associated dental adverse events remain unclear due to the small sample size and inadequate follow-up period.
资助项目	National Natural Science Foundation of China[81773819] ; National Natural Science Foundation of China[81973396] ; Zhejiang Provincial Program for 151 Talents[2017-133]
WOS关键词	DOXYCYCLINE ; TETRACYCLINE
WOS研究方向	Microbiology ; Pharmacology & Pharmacy
语种	英语
出版者	AMER SOC MICROBIOLOGY
WOS记录号	WOS:000707901200038
资助机构	National Natural Science Foundation of China ; Zhejiang Provincial Program for 151 Talents
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/125597]
专题	中国科学院合肥物质科学研究院
通讯作者	Ruan, Wenhua; Fang, Luo
作者单位	1.Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Pharm,Sch Med, Hangzhou, Zhejiang, Peoples R China 2.Zhejiang Univ, Key Lab Oral Biomed Res Zhejiang Prov, Clin Res Ctr Oral Dis Zhejiang Prov, Stomatol Hosp,Sch Stomatol,Sch Med,Canc Ctr, Hangzhou, Zhejiang, Peoples R China 3.Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Dept Stomatol,Sch Med, Hangzhou, Zhejiang, Peoples R China 4.Chinese Acad Sci, Univ Chinese Acad Sci, Inst Basic Med & Canc IBMC, Dept Pharm,Canc Hosp,Zhejiang Canc Hosp, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Zhengyi,Yu, Qi,Qi, Ganggang,et al. Tigecycline-Induced Tooth Discoloration in Children Younger than Eight Years[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2021,65.
APA	Zhu, Zhengyi.,Yu, Qi.,Qi, Ganggang.,Yang, Jufei.,Ni, Yinghua.,...&Fang, Luo.(2021).Tigecycline-Induced Tooth Discoloration in Children Younger than Eight Years.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,65.
MLA	Zhu, Zhengyi,et al."Tigecycline-Induced Tooth Discoloration in Children Younger than Eight Years".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 65(2021).