Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma | |
Yang, Ke1,2; Wu, Ke1; Feng, Jianguo1; Yutian, Ling1; Zhu, Xin1,2; Xu, Dong1,2 | |
刊名 | EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE |
2021-07-15 | |
卷号 | 2021 |
ISSN号 | 1741-427X |
DOI | 10.1155/2021/5526581 |
通讯作者 | Zhu, Xin(zhuxin@zjcc.org.cn) ; Xu, Dong(xudong@zjcc.org.cn) |
英文摘要 | Objective. To investigate the antitumor effect of andrographolide on the ATC cell lines 8505C and CAL62 and to explore the possible mechanism of the effect. Methods. CCK8 and colony formation assays were performed to detect proliferation. Cell migration was tested by scratch assay. Annexin V/PI staining was used to detect cell apoptosis and cell cycle. Glucose and lactic acid kits were carried out to evaluate the glycolysis level after andrographolide treatment. Western blot was used to detect the changes in the apoptosis-related proteins and glycolysis-related enzymes in both 8505C and CAL62 cells. Results. Treatment with 60 mu M andrographolide had significant effects on 8505C and CAL62, including inhibition of proliferation, inhibition of migration, arrest of the cell cycle, promotion of apoptosis, and inhibition of glycolysis. Conclusion. Andrographolide has an antitumor effect and can significantly affect glycolysis in ATC cells. |
资助项目 | National Natural Science Foundation of China[82072950] |
WOS关键词 | APOPTOSIS ; INHIBITION ; ANTICANCER ; ACTIVATION |
WOS研究方向 | Integrative & Complementary Medicine |
语种 | 英语 |
出版者 | HINDAWI LTD |
WOS记录号 | WOS:000680521900006 |
资助机构 | National Natural Science Foundation of China |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/124338] |
专题 | 中国科学院合肥物质科学研究院 |
通讯作者 | Zhu, Xin; Xu, Dong |
作者单位 | 1.Chinese Acad Sci, Inst Basic Med & Canc IBMC, Zhejiang Canc Hosp, Canc Hosp,Univ Chinese Acad Sci, Hangzhou 310022, Zhejiang, Peoples R China 2.Key Lab Head & Neck Canc Translat Res Zhejiang Pr, Hangzhou 310022, Zhejiang, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Ke,Wu, Ke,Feng, Jianguo,et al. Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021,2021. |
APA | Yang, Ke,Wu, Ke,Feng, Jianguo,Yutian, Ling,Zhu, Xin,&Xu, Dong.(2021).Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2021. |
MLA | Yang, Ke,et al."Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2021(2021). |
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