Magnetic sensitivity of cryptochrome 4 from a migratory songbird

doi:10.1038/s41586-021-03618-9

	Magnetic sensitivity of cryptochrome 4 from a migratory songbird
	Xu, Jingjing 2; Jarocha, Lauren E.3; Zollitsch, Tilo 3; Konowalczyk, Marcin 4; Henbest, Kevin B.3,4; Richert, Sabine 5; Golesworthy, Matthew J.4; Schmidt, Jessica 2; Dejean, Victoire 4; Sowood, Daniel J. C.3
刊名	NATURE
	2021-06-24
卷号	594
ISSN号	0028-0836
DOI	10.1038/s41586-021-03618-9
通讯作者	Solov'yov, Ilia A.(ilia.solovyov@uni-oldenburg.de) ; Xie, Can(canxie@hmfl.ac.cn) ; Mackenzie, Stuart R.(stuart.mackenzie@chem.ox.ac.uk) ; Timmel, Christiane R.(christiane.timmel@chem.ox.ac.uk) ; Mouritsen, Henrik(henrik.mouritsen@uni-oldenburg.de) ; Hore, P. J.(peter.hore@chem.ox.ac.uk)
英文摘要	Night-migratory songbirds are remarkably proficient navigators(1). Flying alone and often over great distances, they use various directional cues including, crucially, a light-dependent magnetic compass(2,3). The mechanism of this compass has been suggested to rely on the quantum spin dynamics of photoinduced radical pairs in cryptochrome flavoproteins located in the retinas of the birds(4-7). Here we show that the photochemistry of cryptochrome 4 (CRY4) from the night-migratory European robin (Erithacus rubecula) is magnetically sensitive in vitro, and more so than CRY4 from two non-migratory bird species, chicken (Gallus gallus) and pigeon (Columba livia). Site-specific mutations of ErCRY4 reveal the roles of four successive flavin-tryptophan radical pairs in generating magnetic field effects and in stabilizing potential signalling states in a way that could enable sensing and signalling functions to be independently optimized in night-migratory birds.
资助项目	Air Force Office of Scientific Research (Air Force Materiel Command, USAF)[FA9550-14-1-0095] ; European Research Council (European Union)[810002] ; Office of Naval Research Global[N62909-19-1-2045] ; Deutsche Forschungsgemeinschaft[SFB 1372] ; Deutsche Forschungsgemeinschaft[395940726] ; Deutsche Forschungsgemeinschaft[GRK 1885] ; DAAD (German Academic Exchange Service, Graduate School Scholarship Programme)[57395813] ; SCG Innovation Fund ; Electromagnetic Fields Biological Research Trust ; National Natural Science Foundation of China[31640001] ; Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences[BJZX201901] ; Lundbeck Foundation ; Danish Councils for Independent Research ; Volkswagen Foundation ; Biotechnology and Biological Sciences Research Council[BB/M011224/1] ; Clarendon Fund ; CAESR, Engineering and Physical Sciences Research Council[EP/L011972/1] ; Clarendon Fund, University of Oxford
WOS关键词	RADICAL-PAIR MECHANISM ; ANIMAL CRYPTOCHROMES ; ELECTRON-TRANSFER ; MAGNETORECEPTION ; FIELDS ; MODEL ; ORIENTATION ; CONSISTENT
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	NATURE RESEARCH
WOS记录号	WOS:000665247800015
资助机构	Air Force Office of Scientific Research (Air Force Materiel Command, USAF) ; European Research Council (European Union) ; Office of Naval Research Global ; Deutsche Forschungsgemeinschaft ; DAAD (German Academic Exchange Service, Graduate School Scholarship Programme) ; SCG Innovation Fund ; Electromagnetic Fields Biological Research Trust ; National Natural Science Foundation of China ; Presidential Foundation of Hefei Institutes of Physical Science, Chinese Academy of Sciences ; Lundbeck Foundation ; Danish Councils for Independent Research ; Volkswagen Foundation ; Biotechnology and Biological Sciences Research Council ; Clarendon Fund ; CAESR, Engineering and Physical Sciences Research Council ; Clarendon Fund, University of Oxford
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/123385]
专题	中国科学院合肥物质科学研究院
通讯作者	Solov'yov, Ilia A.; Xie, Can; Mackenzie, Stuart R.; Timmel, Christiane R.; Mouritsen, Henrik; Hore, P. J.
作者单位	1.Carl von Ossietzky Univ Oldenburg, Dept Phys, Oldenburg, Germany 2.Carl von Ossietzky Univ Oldenburg, Inst Biol & Umweltwissensch, AG Neurosensory Sci Anim Nav, Oldenburg, Germany 3.Univ Oxford, Dept Chem, Phys & Theoret Chem Lab, Oxford, England 4.Univ Oxford, Dept Chem, Inorgan Chem Lab, Oxford, England 5.Albert Ludwigs Univ Freiburg, Inst Phys Chem, Freiburg, Germany 6.Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA 7.Carl von Ossietzky Univ Oldenburg, Dept Neurosci, Div Biochem, Oldenburg, Germany 8.Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA 9.Univ Texas Southwestern Med Ctr Dallas, Howard Hughes Med Inst, Dallas, TX 75390 USA 10.Carl von Ossietzky Univ Oldenburg, Res Ctr Neurosensory Sci, Oldenburg, Germany
推荐引用方式 GB/T 7714	Xu, Jingjing,Jarocha, Lauren E.,Zollitsch, Tilo,et al. Magnetic sensitivity of cryptochrome 4 from a migratory songbird[J]. NATURE,2021,594.
APA	Xu, Jingjing.,Jarocha, Lauren E..,Zollitsch, Tilo.,Konowalczyk, Marcin.,Henbest, Kevin B..,...&Hore, P. J..(2021).Magnetic sensitivity of cryptochrome 4 from a migratory songbird.NATURE,594.
MLA	Xu, Jingjing,et al."Magnetic sensitivity of cryptochrome 4 from a migratory songbird".NATURE 594(2021).