A multifunctional surfactant catalyst inspired by hydrolases

doi:10.1126/sciadv.aaz0404

	A multifunctional surfactant catalyst inspired by hydrolases
	Nothling, Mitchell D.6; Xiao, Zeyun 1; Hill, Nicholas S.5; Blyth, Mitchell T.5; Bhaskaran, Ayana 5; Sani, Marc-Antoine 4; Espinosa-Gomez, Andrea 6; Ngov, Kevin 6; White, Jonathan 4; Buscher, Tim 3
刊名	SCIENCE ADVANCES
	2020-04-01
卷号	6 期号:14 页码:12
ISSN号	2375-2548
DOI	10.1126/sciadv.aaz0404
通讯作者	Connal, Luke A.(luke.connal@anu.edu.au)
英文摘要	The remarkable power of enzymes to undertake catalysis frequently stems from their grouping of multiple, complementary chemical units within close proximity around the enzyme active site. Motivated by this, we report here a bioinspired surfactant catalyst that incorporates a variety of chemical functionalities common to hydrolytic enzymes. The textbook hydrolase active site, the catalytic triad, is modeled by positioning the three groups of the triad (-OH, -imidazole, and -CO2H) on a single, trifunctional surfactant molecule. To support this, we recreate the hydrogen bond donating arrangement of the oxyanion hole by imparting surfactant functionality to a guanidinium headgroup. Self-assembly of these amphiphiles in solution drives the collection of functional headgroups into close proximity around a hydrophobic nano-environment, affording hydrolysis of a model ester at rates that challenge alpha-chymotrypsin. Structural assessment via NMR and XRD, paired with MD simulation and QM calculation, reveals marked similarities of the co-micelle catalyst to native enzymes.
资助项目	U.S. Army International Technology Centre Pacific ITC-PAC[FA5209-14-C-0017] ; Australian Research Council (ARC)[DP200100535] ; Australia Science Endowment Fund (SIEF) ; ARC Centre of Excellence for Electromaterials Science[CE140100012] ; ARC Laureate Fellowship[FL170100041]
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000523302400023
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/10752]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Connal, Luke A.
作者单位	1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Australian Natl Univ, ARC Ctr Excellence Electromat Sci, Res Sch Chem, Canberra, ACT 2601, Australia 3.Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA 4.Univ Melbourne, Sch Chem, Bio21 Inst, Melbourne, Vic 3010, Australia 5.Australian Natl Univ, Res Sch Chem, Canberra, ACT 2601, Australia 6.Univ Melbourne, Dept Chem & Biomol Engn, Melbourne, Vic 3010, Australia
推荐引用方式 GB/T 7714	Nothling, Mitchell D.,Xiao, Zeyun,Hill, Nicholas S.,et al. A multifunctional surfactant catalyst inspired by hydrolases[J]. SCIENCE ADVANCES,2020,6(14):12.
APA	Nothling, Mitchell D..,Xiao, Zeyun.,Hill, Nicholas S..,Blyth, Mitchell T..,Bhaskaran, Ayana.,...&Connal, Luke A..(2020).A multifunctional surfactant catalyst inspired by hydrolases.SCIENCE ADVANCES,6(14),12.
MLA	Nothling, Mitchell D.,et al."A multifunctional surfactant catalyst inspired by hydrolases".SCIENCE ADVANCES 6.14(2020):12.