Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy

doi:10.1016/j.saa.2019.117736

	Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy
	Tang, Mingjie 2,3; Xia, Liangping 2,4; Wei, Dongshan 1,2; Yan, Shihan 2; Zhang, Mingkun 2; Yang, Zhongbo 2; Wang, Huabin 2; Du, Chunlei 2; Cui, Hong-Liang 2
刊名	SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
	2020-03-05
卷号	228 页码:5
关键词	Fatty acid Terahertz time-domain spectroscopy Label-free THz sensor Dielectric constant
ISSN号	1386-1425
DOI	10.1016/j.saa.2019.117736
通讯作者	Du, Chunlei() ; Cui, Hong-Liang(hcui@cigit.ac.cn)
英文摘要	A rapid method for detecting fatty acids (FAs) using terahertz time-domain spectroscopy (THz-TDS) technology combined with a metamaterial-based THz sensor was developed. We measured the THz responses to oleic acid, linoleic acid and alpha-linoleic acid with different numbers of double-bond, alpha-linoleic acid and gamma-linoleic acid with different conformations. In addition, in order to explore the reason for the observed redshifts of the resonance frequencies of the four FAs, the dielectric constants of the FAs were measured in the THz region. Furthermore, the four fatty acids were also attempted to be identified by Raman spectroscopy, which was difficult to accomplish unambiguously because of the effect of fluorescence. This result thus demonstrates the power and usefulness of metamaterial-assisted THz-TDS in the rapid determination of the FAs, and its potential as a versatile tool for investigation of biological metabolism, and for food product quality, safety inspection and control. (C) 2019 Published by Elsevier B.V.
资助项目	National Key Research and Development Program of China[2017YFF0106303] ; Central Government Supported Key Instrument Program of China[YXGYQ201700136] ; Natural Science Foundation of Chongqing[cstc2019jcyj-msxmX0654] ; Natural Science Foundation of Chongqing[cstc2019jcyj-msxmX0352] ; National Natural Science Foundation of China[61605206] ; National Natural Science Foundation of China[11604332] ; National Natural Science Foundation of China[61775213] ; National Natural Science Foundation of China[61875196]
WOS研究方向	Spectroscopy
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000513010500056
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/10560]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Du, Chunlei; Cui, Hong-Liang
作者单位	1.Dongguan Univ Technol, Sch Elect Engn & Intelligentizat, Dongguan 523808, Guangdong, Peoples R China 2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yangtze Normal Univ, Sch Elect Informat Engn, Chongqing 408100, Peoples R China
推荐引用方式 GB/T 7714	Tang, Mingjie,Xia, Liangping,Wei, Dongshan,et al. Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,2020,228:5.
APA	Tang, Mingjie.,Xia, Liangping.,Wei, Dongshan.,Yan, Shihan.,Zhang, Mingkun.,...&Cui, Hong-Liang.(2020).Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,228,5.
MLA	Tang, Mingjie,et al."Rapid and label-free metamaterial-based biosensor for fatty acid detection with terahertz time-domain spectroscopy".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 228(2020):5.