Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China

doi:10.1016/j.jhazmat.2019.121106

	Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China
	Hamid, Naima 1,2; Junaid, Muhammad 1,2; Pei, De-Sheng 1,2,3
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2020-01-15
卷号	382 页码:11
关键词	Acinetobacter sp. Tox2 Combine toxicity Detoxification Predictive models Zebrafish
ISSN号	0304-3894
DOI	10.1016/j.jhazmat.2019.121106
通讯作者	Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要	Sulfonamides (SAs) are conventional veterinary antibiotics that pose ecological risks in the aquatic environment. This study aims to evaluate the environmental concerns of SAs in the Three Gorges Reservoir Area (TGRA) and their toxicogenetic implications. Here, we employed various in vitro and in vivo bioassays to determine the combine toxicogenetic effects of SAs, which were further confirmed through applying Combination Index (CI) and Independent Action (IA) models. Among the investigated SAs, sulfamethoxazole (SMX) appeared as the individual chemical with relatively high environmental effects and elevated in vitro and in vivo toxicity. Importantly, exposure to the binary mixtures of SAs induced higher developmental toxicity and significantly perturbed the detoxification pathway in zebrafish, compared to that of individual compound exposure. Moreover, the CI and IA models indicated greater synergistic effects of SAs binary mixtures as SMX-SMR, SMX-ST, and SPY-ST on the Acinetobacter sp. Tox2 at Fa = 0.5. Contrarily, IA model predicted the additive, antagonistic and synergistic effects of SAs mixtures on the transcriptional responses of detoxification pathways in zebrafish, implying the different mode of actions (MoAs) for SAs to induce mixture toxicity in vivo. Thus, the nature of toxicological interactions of SAs should be considered while performing their ecological risk assessment.
资助项目	Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714] ; CASTWAS Scholarship[2017A8018537001]
WOS研究方向	Engineering ; Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000501387100084
内容类型	期刊论文
源URL	[http://119.78.100.138/handle/2HOD01W0/10076]
专题	中国科学院重庆绿色智能技术研究院
通讯作者	Pei, De-Sheng
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Reservoir Aquat Environm, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 3.Henan Normal Univ, Coll Life Sci, Xinxiang 453007, Henan, Peoples R China
推荐引用方式 GB/T 7714	Hamid, Naima,Junaid, Muhammad,Pei, De-Sheng. Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China[J]. JOURNAL OF HAZARDOUS MATERIALS,2020,382:11.
APA	Hamid, Naima,Junaid, Muhammad,&Pei, De-Sheng.(2020).Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China.JOURNAL OF HAZARDOUS MATERIALS,382,11.
MLA	Hamid, Naima,et al."Individual and combined mechanistic toxicity of sulfonamides and their implications for ecological risk assessment in the Three Gorges Reservoir Area (TGRA), China".JOURNAL OF HAZARDOUS MATERIALS 382(2020):11.