Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)

CORC > 海洋研究所 > 中国科学院海洋研究所 > 海洋生态与环境科学重点实验室

	Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)
	Zhao Heling 1,2; Yang Hongsheng1 ; Zhao Huan 1,2; Liu Shilin 1; Wang Tianming 1,2
刊名	CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY
	2012
卷号	30 期号:1 页码:80-91
关键词	microphthalmia-associated transcription factor (MITF) melanocyte melanosome melanin Apostichopus japonicus
ISSN号	0254-4059
通讯作者	Yang, HS (reprint author), Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China.
英文摘要	Albino Apostichopus japonicus occur both in the wild and in captivity. The offspring of albino A. japonicus also suffer from albinism. The formation of melanin in the melanocytes is dependant on microphthalmia-associated transcription factor (MITF). To investigate the role of MITF in controlling albinism, we cloned the full-length MITF cDNA from A. japonicus and compared MITF mRNA expression in albino and normal A. japonicus. In addition, we used light and electron microscopy to compare histological samples of normal and albino A. japonicus. The body wall of albino adults was characterized by significantly lower levels of MITF expression and lower numbers of epidermal melanocytes, which also contained less melanin. In albino juvenile offspring, MITF expression levels were significantly lower 32 d after fertilization and there were fewer, and less developed, epidermal melanocytes. Thus, we conclude that albino A. japonicus have fewer melanocytes and a reduced ability to synthesize melanin, likely because of lower expression of MITF.
学科主题	Limnology ; Oceanography
收录类别	SCI
原文出处	10.1007/s00343-012-1043-9
语种	英语
WOS记录号	WOS:000299040100008
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12418]
专题	海洋研究所_海洋生态与环境科学重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Marine Ecol & Environm Sci, Inst Oceanol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhao Heling,Yang Hongsheng,Zhao Huan,et al. Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)[J]. CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2012,30(1):80-91.
APA	Zhao Heling,Yang Hongsheng,Zhao Huan,Liu Shilin,&Wang Tianming.(2012).Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka).CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY,30(1),80-91.
MLA	Zhao Heling,et al."Differences in MITF gene expression and histology between albino and normal sea cucumbers (Apostichopus japonicus Selenka)".CHINESE JOURNAL OF OCEANOLOGY AND LIMNOLOGY 30.1(2012):80-91.