Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption

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	Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption
	Wang JL(王九令); Wei YJ(魏宇杰); Shi XH(施兴华); Gao HJ
刊名	RSC ADVANCES
	2013-09-28
通讯作者邮箱	shixh@imech.ac.cn
卷号	3 期号:36 页码:15776-15782
关键词	Carbon Nanotubes Graphene Nanosheets Lipid-Bilayers Coarse-Grained Model Molecular-Dynamics Hydrophobicity Surface Absorption Oxidation Bio Medical DiagnosticsCarbon Nanotubes Graphene Nanosheets Lipid-Bilayers Coarse-Grained Model Molecular-Dynamics Hydrophobicity Surface Absorption Oxidation Bio Medical Diagnostics
ISSN号	2046-2069
通讯作者	Shi, XH (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China.
产权排序	[Wang, Jiuling; Wei, Yujie; Shi, Xinghua] Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China; [Gao, Huajian] Brown Univ, Sch Engn, Providence, RI 02912 USA
合作状况	国际
中文摘要	Coarse grained molecular dynamics simulations are conducted to study the interaction of graphene nanosheets with a lipid bilayer, focusing on the effects of graphene thicknesses (single/multi-layered graphene), oxidation and surface absorption by lipid molecules. The results show that a hydrophobic corner of graphene can pierce into the bilayer, while different oxidations of the nanosheets affect their final equilibrium configurations in the bilayer: lying across or within the hydrophobic core of the bilayer. The underlying mechanism is clarified by calculating the energy barrier for graphene piercing into the bilayer. Our studies provide fundamental guidance towards understanding how graphene enters cells, which is important for biomedical diagnostics and therapies, and for managing health impacts following occupational or environmental exposure.
学科主题	固体力学
分类号	二类/Q2
收录类别	SCI ; EI
资助信息	National Natural Science Foundation of China (NSFC) [11272327]; National Science Foundation (NSF) [CMMI-1028530]; Supercomputing Center of Chinese Academy of Sciences (SCCAS)
原文出处	http://dx.doi.org/10.1039/c3ra40392k
语种	英语
WOS记录号	WOS:000323271700037
公开日期	2013-09-27
内容类型	期刊论文
源URL	[http://dspace.imech.ac.cn/handle/311007/47462]
专题	力学研究所_非线性力学国家重点实验室
推荐引用方式 GB/T 7714	Wang JL,Wei YJ,Shi XH,et al. Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption[J]. RSC ADVANCES,2013,3(36):15776-15782.
APA	Wang JL,Wei YJ,Shi XH,&Gao HJ.(2013).Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption.RSC ADVANCES,3(36),15776-15782.
MLA	Wang JL,et al."Cellular entry of graphene nanosheets: The role of thickness, oxidation and surface adsorption".RSC ADVANCES 3.36(2013):15776-15782.