Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities.

doi:10.1016/j.phytochem.2020.112648

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	Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities.
	Tuohongerbieke, Amanguli ; Li, Jun ; Sabir, Gulnar ; Xin, Xuelei ; Hu, Miao ; Duan, Xiaomei ; Liu, Liu ; Tang, Dan ; Zhu, Jun ; Aisa, Haji Akber
刊名	Phytochemistry
	2021
卷号	184 期号:4 页码:1-10
关键词	Anti-diabetic Anti-inflammatory Cytotoxic Lignanamides Limonium gmelinii (Willd.) Kuntze Plumbaginaceae
DOI	10.1016/j.phytochem.2020.112648
英文摘要	Nine undescribed lignanamides, limoniumins A-I, together with ten known lignanamides and two known phenolics were isolated from ethyl acetate extract of the roots of Limonium gmelinii (Plumbaginaceae). Their structures were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. Limoniumin A is the first hybrid lignanamide of phenylpropanoid and coumarin. All tested lignanamides showed significant inhibitory activity against alpha-glucosidase stronger than positive control and remarkable inhibitory effect to PTP1B with IC50 values less than 10muM. In addition, some lignanamides exhibited moderate cytotoxic activity against HeLa and MCF-7cells and anti-inflammatory activity against COX-2 in a dose-dependent way.
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/7721]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
通讯作者	Aisa, Haji Akber
作者单位	1.Xinjiang Institute of Chinese Material Medica and Ethnomedicine, Urumqi, 830002, People's Republic of China 2.University of Chinese Academy of Sciences, Beijing, 100039, PR China 3.The Key Laboratory of Plant Resources and Chemistry of Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences,
推荐引用方式 GB/T 7714	Tuohongerbieke, Amanguli,Li, Jun,Sabir, Gulnar,et al. Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities.[J]. Phytochemistry,2021,184(4):1-10.
APA	Tuohongerbieke, Amanguli.,Li, Jun.,Sabir, Gulnar.,Xin, Xuelei.,Hu, Miao.,...&Aisa, Haji Akber.(2021).Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities..Phytochemistry,184(4),1-10.
MLA	Tuohongerbieke, Amanguli,et al."Lignanamides from the roots of Limonium gmelinii (Willd.) Kuntze and their anti-diabetic, cytotoxic and anti-inflammatory activities.".Phytochemistry 184.4(2021):1-10.