Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis

doi:10.1021/acs.jnatprod.8b00461

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	Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis
	Liu, YS (Liu, Yushuang)[ 1,2,3 ]; Chen, GY (Chen, Guangying)[ 4 ]; Chen, XY (Chen, Xiaoyu)[ 1,2,3 ]; Chen, SX (Chen, Shi-Xin)[ 5 ]; Gan, LS (Gan, Li-She)[ 5 ]; Yuan, T (Yuan, Tao)[ 1,2 ]
刊名	JOURNAL OF NATURAL PRODUCTS
	2020
卷号	81 期号:9 页码:2115-2119
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.8b00461
英文摘要	Four ring-A seco-cucurbitane triterpenoids, colocynthenins A-D (1-4), together with seven known cucurbitane triterpenoids (5-11), were isolated from the fruits of Citrullus colocynthis. Their structures and absolute configurations were elucidated based on spectroscopic analysis and quantum chemical ECD calculations. Compound 1 possesses an unprecedented 2,11-lactone moiety, while compound 2 is the first reported cucurbitane triterpenoid with an unusual cyano group. Compounds 1 and 3 showed acetylcholinesterase inhibitory activities in a standard in vitro assay, with IC50 values of 2.6 and 3.1 mu M, respectively.
WOS记录号	WOS:000446276600026
内容类型	期刊论文
源URL	[http://ir.xjipc.cas.cn/handle/365002/7339]
专题	新疆理化技术研究所_省部共建新疆特有药用资源利用重点实验室
作者单位	1.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China 2.Hainan Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Trop Med Plant Chem, Haikou 571158, Hainan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, State Key Lab Xinjiang Indigenous Med Plants Reso, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China 5.Chinese Acad Sci, Key Lab Plant Resources & Chem Arid Zone, Xinjiang Tech Inst Phys & Chem, Urumqi 830011, Peoples R China
推荐引用方式 GB/T 7714	Liu, YS ,Chen, GY ,Chen, XY ,et al. Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis[J]. JOURNAL OF NATURAL PRODUCTS,2020,81(9):2115-2119.
APA	Liu, YS ,Chen, GY ,Chen, XY ,Chen, SX ,Gan, LS ,&Yuan, T .(2020).Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis.JOURNAL OF NATURAL PRODUCTS,81(9),2115-2119.
MLA	Liu, YS ,et al."Colocynthenins A-D, Ring-A seco-Cucurbitane Triterpenoids from the Fruits of Citrullus colocynthis".JOURNAL OF NATURAL PRODUCTS 81.9(2020):2115-2119.