Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells

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	Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells
	Zhang, Zhenwei 2; Miao, Lei 3; Sun, Weizhang 4; Jiao, Binghua 2; Wang, Bingui1 ; Yao, Li 3; Huang, Caiguo 2
刊名	BIOLOGICAL & PHARMACEUTICAL BULLETIN
	2012-11-01
卷号	35 期号:11 页码:1964-1971
关键词	Wentilactone B apoptosis migration SMMC-7721 Chang
ISSN号	0918-6158
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China.
英文摘要	Wentilactone B (EN-48-57) is one of the six derivatives separated from Aspergillus wentii (EN-48). Of these derivatives, Wentilactone B exerted a more significant antibacterial and cytotoxic activity in several tumor cell lines. The present study demonstrates that Wentilactone B could efficiently induce SMMC-7721 cells apoptosis, but not normal hepatic cells, as measured by an inverted microscope, 4',6-diamidino-2-phenylindole staining and flow cytometry. In addition, Wentilactone B could inhibit the metastasis of SMMC-7721 cells, which was detected by colony formation, scratch migration and a transwell assay, and could induce a series of intracellular events, including the down-regulation of CD44 and epidermal growth factor receptor proteins. In conclusion, Wentilactone B inhibited the growth of SMMC-7721 cells by triggering apoptosis and inhibiting metastasis.
学科主题	Pharmacology & Pharmacy
收录类别	SCI
语种	英语
WOS记录号	WOS:000310662700017
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12406]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Second Mil Med Univ, Dept Biochem & Mol Biol, Shanghai 200433, Peoples R China 3.Zhejiang Chinese Med Univ, Dept Pharmacol, Hangzhou 310053, Zhejiang, Peoples R China 4.Gen Hosp Chengdu Mil Command, PET Ctr, Chengdu 610083, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Zhenwei,Miao, Lei,Sun, Weizhang,et al. Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells[J]. BIOLOGICAL & PHARMACEUTICAL BULLETIN,2012,35(11):1964-1971.
APA	Zhang, Zhenwei.,Miao, Lei.,Sun, Weizhang.,Jiao, Binghua.,Wang, Bingui.,...&Huang, Caiguo.(2012).Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells.BIOLOGICAL & PHARMACEUTICAL BULLETIN,35(11),1964-1971.
MLA	Zhang, Zhenwei,et al."Wentilactone B from Aspergillus wentii Induces Apoptosis and Inhibits Proliferation and Migration of Human Hepatoma SMMC-7721 Cells".BIOLOGICAL & PHARMACEUTICAL BULLETIN 35.11(2012):1964-1971.