Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220

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	Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220
	Du, Feng-Yu 1,2; Li, Xiao-Ming 1; Li, Chun-Shun 1; Shang, Zhuo 1; Wang, Bin-Gui1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
	2012-07-15
卷号	22 期号:14 页码:4650-4653
关键词	Marine endophyte Eurotium cristatum Indole alkaloid Antimicrobial activity Brine shrimp inhibition
ISSN号	0960-894X
通讯作者	Wang, BG (reprint author), Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Peoples R China.
英文摘要	Four new indole alkaloids, namely, cristatumins A-D (1-4), along with six known congeners (5-10) were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii. The structures of these compounds were established on the basis of extensive spectroscopic analysis. Each of these compounds was evaluated for antimicrobial and insecticidal activity. Compounds 1 and 9 showed antibacterial activity against Escherichia coli and Staphyloccocus aureus, respectively, while compounds 2, 6, and 7 exhibited moderate lethal activity against brine shrimp. Preliminary structure-activity relationships were also discussed. (C) 2012 Elsevier Ltd. All rights reserved.
学科主题	Chemistry, Medicinal ; Chemistry, Organic
收录类别	SCI
原文出处	10.1016/j.bmcl.2012.05.088
语种	英语
WOS记录号	WOS:000306101300030
公开日期	2013-09-24
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/12307]
专题	海洋研究所_实验海洋生物学重点实验室
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Du, Feng-Yu,Li, Xiao-Ming,Li, Chun-Shun,et al. Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2012,22(14):4650-4653.
APA	Du, Feng-Yu,Li, Xiao-Ming,Li, Chun-Shun,Shang, Zhuo,&Wang, Bin-Gui.(2012).Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,22(14),4650-4653.
MLA	Du, Feng-Yu,et al."Cristatumins A-D, new indole alkaloids from the marine-derived endophytic fungus Eurotium cristatum EN-220".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22.14(2012):4650-4653.