Biomimetic camouflage delivery strategies for cancer therapy

doi:10.1039/d1nr01127h

	Biomimetic camouflage delivery strategies for cancer therapy
	Asrorov, Akmal M.1,2; Gu, Zeyun 1; Li, Feng 3; Liu, Lingyun 4; Huang, Yongzhuo 1,5,6
刊名	NANOSCALE
	2021-05-04
页码	14
ISSN号	2040-3364
DOI	10.1039/d1nr01127h
通讯作者	Li, Feng(fzl0023@auburn.edu) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要	Cancer remains a significant challenge despite the progress in developing different therapeutic approaches. Nanomedicine has been explored as a promising novel cancer therapy. Recently, biomimetic camouflage strategies have been investigated to change the bio-fate of therapeutics and target cancer cells while reducing the unwanted exposure on normal tissues. Endogenous components (e.g., proteins, polysaccharides, and cell membranes) have been used to develop anticancer drug delivery systems. These biomimetic systems can overcome biological barriers and enhance tumor cell-specific uptake. The tumor-targeting mechanisms include ligand-receptor interactions and stimuli-responsive (e.g., pH-sensitive and light-sensitive) delivery. Drug delivery carriers composed of endogenous components represent a promising approach for improving cancer treatment efficacy. In this paper, different biomimetic drug delivery strategies for cancer treatment are reviewed with a focus on the discussion of their advantages and potential applications.
资助项目	National Key Research and Development Program of China[2019YFE0129400] ; NFSC[81925035] ; NFSC[81521005] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010002] ; Shanghai Sci-Tech Innovation Action Plan[19431903100] ; CAS PIFI Fellowship[2019PB0076] ; Belt & Road Young Scientist Award (Shanghai)[18430740800] ; Guangzhou Science and Technology Planning Project[201707010319]
WOS关键词	LOW-DENSITY-LIPOPROTEIN ; MESOPOROUS SILICA NANOPARTICLES ; HYALURONIC-ACID ; DRUG-DELIVERY ; TARGETED DELIVERY ; ALBUMIN NANOPARTICLES ; PHOTODYNAMIC THERAPY ; ERYTHROCYTE-MEMBRANE ; CO-DELIVERY ; TUMOR
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000646799100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296501]
专题	中国科学院上海药物研究所
通讯作者	Li, Feng; Huang, Yongzhuo
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Acad Sci Uzbek, Inst Bioorgan Chem, 83 M Ulughbek St, Tashkent 100125, Uzbekistan 3.Auburn Univ, Harrison Sch Pharm, Auburn, AL 36849 USA 4.Guangzhou Univ Chinese Med, Clin Sch 1, Guangzhou 510450, Peoples R China 5.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Inst Drug Discovery & Dev, Zhongshan 528437, Peoples R China 6.NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Asrorov, Akmal M.,Gu, Zeyun,Li, Feng,et al. Biomimetic camouflage delivery strategies for cancer therapy[J]. NANOSCALE,2021:14.
APA	Asrorov, Akmal M.,Gu, Zeyun,Li, Feng,Liu, Lingyun,&Huang, Yongzhuo.(2021).Biomimetic camouflage delivery strategies for cancer therapy.NANOSCALE,14.
MLA	Asrorov, Akmal M.,et al."Biomimetic camouflage delivery strategies for cancer therapy".NANOSCALE (2021):14.