Cocrystals to tune oily vitamin E into crystal vitamin E

doi:10.1016/j.ijpharm.2020.120057

	Cocrystals to tune oily vitamin E into crystal vitamin E
	Zhu, Bingqing; Zhang, Qi; Lu, Liye; Bao, Junjie; Rong, Xiaoyi; Wang, Jian-Rong; Mei, Xuefeng
刊名	INTERNATIONAL JOURNAL OF PHARMACEUTICS
	2021-01-05
卷号	592 页码:8
关键词	Cocrystal Vitamin E Solidification Stability Bioavailability
ISSN号	0378-5173
DOI	10.1016/j.ijpharm.2020.120057
通讯作者	Mei, Xuefeng(xuefengmei@simm.ac.cn)
英文摘要	d-alpha-tocopherol (d-alpha Toc), the most biologically active form of natural Vitamin E, is oily in appearance and unstable to oxygen. Esterification and encapsulation are generally needed to stabilize and solidify d-alpha Toc for the purpose of its expanding applications. In this study, we propose a more effective way to stabilize and solidify d-alpha Toc oil in one step. By cocrystallization, the melting point of d-alpha Toc is significantly increased, such that the oily d-alpha Toc is successfully transformed into solid form at room temperature. The single crystal structure of d-croc was firstly uncovered and the molecular interaction in cocrystals was revealed. Crystalline Vitamin E shows high stability to light and temperature. Its spherical crystallization affords good powder flowability, which is extremely important as food or feed additives. Moreover, cocrystal Vitamin E remains the original form of tocopherol without esterification and thus has a great advantage on higher bioavailability. Cocrystallization of oily d-alpha Toc spares the use of acetic ester and a mass of excipients, which is of great environmental importance and greatly reduces the production cost.
WOS关键词	ACETATE ; DRUG
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000600740100039
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296372]
专题	中国科学院上海药物研究所
通讯作者	Mei, Xuefeng
作者单位	Chinese Acad Sci, Shanghai Inst Mat Med, Pharmaceut Analyt & Solid State Chem Res Ctr, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Bingqing,Zhang, Qi,Lu, Liye,et al. Cocrystals to tune oily vitamin E into crystal vitamin E[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS,2021,592:8.
APA	Zhu, Bingqing.,Zhang, Qi.,Lu, Liye.,Bao, Junjie.,Rong, Xiaoyi.,...&Mei, Xuefeng.(2021).Cocrystals to tune oily vitamin E into crystal vitamin E.INTERNATIONAL JOURNAL OF PHARMACEUTICS,592,8.
MLA	Zhu, Bingqing,et al."Cocrystals to tune oily vitamin E into crystal vitamin E".INTERNATIONAL JOURNAL OF PHARMACEUTICS 592(2021):8.