Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis

doi:10.1002/adfm.202006214

	Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis
	He, Chao 1; Yu, Luodan 2; Yao, Heliang 3; Chen, Yu 2; Hao, Yongqiang 1
刊名	ADVANCED FUNCTIONAL MATERIALS
	2020-12-13
页码	14
关键词	bone metastasis breast cancer checkpoint blockade immunotherapy osteogenesis photothermal therapy
ISSN号	1616-301X
DOI	10.1002/adfm.202006214
通讯作者	Yu, Luodan(yuluodan@shu.edu.cn) ; Chen, Yu(chenyuedu@shu.edu.cn) ; Hao, Yongqiang(haoyq1664@sh9hospital.org.cn)
英文摘要	Cancer metastases are the main causes for the high mortality of cancer. The current treatment modality for bone metastasis of breast cancer is dominantly destructive, which urges the engineering of multifunctional biomaterials, not only for eliminating primary/metastases tumors effectively but also for enhancing bone-tissue regeneration. Herein, an immune adjuvant (R837)-loaded and niobium carbide (Nb2C) MXene-modified 3D-printing biodegradable scaffold (BG@NbSiR) is designed and constructed to effectively treat bone metastasis of breast cancer. The engineered BG@NbSiR scaffold can eradicate primary tumors, activate the immune response, suppress metastases, prevent tumor relapses (long-term immunological memory) by synergizing with checkpoint blockade immunotherapy, and accelerate osteogenesis as evidenced by multiple in vivo murine models. In particular, single-cell sequencing (scRNA-seq) is employed to further determine the critical factors responding to BG@NbSiR scaffold-based photothermia plus checkpoint blockade-combined immunotherapy. Several gene functional terms are identified in both tumor biology (including copy number variation) and immune response, which further reveal the underlying therapeutic mechanisms from the perspective of single-cell transcriptome. This work not only demonstrates the promising clinical application potentials of BG@NbSiR scaffold-based therapy against bone metastasis of breast cancer, but also provides distinctive avenues to optimize the design and construction of multifunctional tissue-engineering biomaterials based on single-cell genomes.
资助项目	Oebiotech Co., Ltd. ; National Key R&D Program of China[2016YFC1100600] ; National Key R&D Program of China[2016YFA0203700] ; National Natural Science Foundation of China[51672303] ; National Natural Science Foundation of China[81972058] ; Excellent Young Scientist Foundation of NSFC[51722211] ; Program of Shanghai Subject Chief Scientist[18XD1404300] ; Youth Program of National Natural Science Foundation of China[51902334] ; Xuemei Tong's lab
WOS关键词	T-CELL ; METASTASES ; RESISTANCE
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000598309400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/296222]
专题	中国科学院上海药物研究所
通讯作者	Yu, Luodan; Chen, Yu; Hao, Yongqiang
作者单位	1.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Orthoped Surg,Shanghai Key Lab Orthoped Impl, Shanghai 200011, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 2000444, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Ceram, Anal & Testing Ctr Inorgan Mat, Shanghai 200050, Peoples R China
推荐引用方式 GB/T 7714	He, Chao,Yu, Luodan,Yao, Heliang,et al. Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis[J]. ADVANCED FUNCTIONAL MATERIALS,2020:14.
APA	He, Chao,Yu, Luodan,Yao, Heliang,Chen, Yu,&Hao, Yongqiang.(2020).Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis.ADVANCED FUNCTIONAL MATERIALS,14.
MLA	He, Chao,et al."Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis".ADVANCED FUNCTIONAL MATERIALS (2020):14.