Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry

doi:10.1016/j.cclet.2020.11.037

	Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry
	Li, Yufen 2; Li, Songwei 2,3; Cuadrado, Cristina 4; Gao, Chenglong 1; Wu, Qihao 2; Li, Xiaolu 2; Pang, Tao 1; Daranas, Antonio Hernandez 4; Guo, Yuewei 2; Li, Xuwen 2
刊名	CHINESE CHEMICAL LETTERS
	2021
卷号	32 期号:1 页码:271-276
关键词	Soft coral Sarcophyton tortuosum Biscembranoid Stereochemistry Anti-inflammatory
ISSN号	1001-8417
DOI	10.1016/j.cclet.2020.11.037
通讯作者	Daranas, Antonio Hernandez(adaranas@ull.edu.es) ; Guo, Yuewei(ywguo@simm.ac.cn) ; Li, Xuwen(xwli@simm.ac.cn)
英文摘要	Five novel biscembranoids, ximaolides H-L (1-5), along with four known related compounds (6-9) were isolated from the Hainan soft coral Sarcophyton tortuosum. The structures of the new compounds were determined by extensive spectroscopic analysis, quantum chemical calculations, and/or by comparing their CD spectra with those of the known compounds. Compounds 1 and 2 are the first examples of biscembranoids bearing a 1,35-bridged lactone moiety, 4 is the first biscembranoid comprising an uncommon oxetane ring, and 5 represents the first 36-peroxyl biscembranoid. Ximaolides I (2), K (4) and F (9) exhibited interesting anti-inflammatory activity by the inhibition of LPS-induced TNF-alpha protein release in RAW264.7 macrophages. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China (NSFC)[81991521] ; National Natural Science Foundation of China (NSFC)[8202290170] ; National Natural Science Foundation of China (NSFC)[42076099] ; NSFC/CNRS (Centre National de la Recherche Scientifique) Joint Project[81811530284] ; National Key Research and Development Program of China[2018YFC0310903] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Shanghai Rising-Star Program[20QA1411100]
WOS研究方向	Chemistry
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000618541800048
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295556]
专题	中国科学院上海药物研究所
通讯作者	Daranas, Antonio Hernandez; Guo, Yuewei; Li, Xuwen
作者单位	1.China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, State Key Lab Nat Med, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China 4.Inst Prod Nat & Agrobiol, Consejo Super Invest Cient IPNA CSIC, San Cristobal la Laguna 38206, Spain
推荐引用方式 GB/T 7714	Li, Yufen,Li, Songwei,Cuadrado, Cristina,et al. Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry[J]. CHINESE CHEMICAL LETTERS,2021,32(1):271-276.
APA	Li, Yufen.,Li, Songwei.,Cuadrado, Cristina.,Gao, Chenglong.,Wu, Qihao.,...&Li, Xuwen.(2021).Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry.CHINESE CHEMICAL LETTERS,32(1),271-276.
MLA	Li, Yufen,et al."Polyoxygenated anti-inflammatory biscembranoids from the soft coral Sarcophyton tortuosum and their stereochemistry".CHINESE CHEMICAL LETTERS 32.1(2021):271-276.