Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy

doi:10.1002/advs.202003542

	Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy
	Zhu, Runqi 1,3,4; Lang, Tianqun 1,3,4,5; Yan, Wenlu 1,3,4; Zhu, Xiao 1,3,4; Huang, Xin 1,3,4; Yin, Qi 1,3,4,5; Li, Yaping 1,2,3,4,5
刊名	ADVANCED SCIENCE
	2021-03-09
页码	32
关键词	cancer therapy carcinogenesis drug delivery system gut microbiota modulation
DOI	10.1002/advs.202003542
通讯作者	Yin, Qi(qyin@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要	Gut microbiota have close interactions with the host. It can affect cancer progression and the outcomes of cancer therapy, including chemotherapy, immunotherapy, and radiotherapy. Therefore, approaches toward the modulation of gut microbiota will enhance cancer prevention and treatment. Modern drug delivery systems (DDS) are emerging as rational and promising tools for microbiota intervention. These delivery systems have compensated for the obstacles associated with traditional treatments. In this review, the essential roles of gut microbiota in carcinogenesis, cancer progression, and various cancer therapies are first introduced. Next, advances in DDS that are aimed at enhancing the efficacy of cancer therapy by modulating or engineering gut microbiota are highlighted. Finally, the challenges and opportunities associated with the application of DDS targeting gut microbiota for cancer prevention and treatment are briefly discussed.
资助项目	National Natural Science Foundation of China[81871471] ; National Natural Science Foundation of China[31930066] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Natural Science Foundation of Shanghai[19ZR1479900] ; Natural Science Foundation of Shandong[ZR2019ZD25] ; Key Scientific Research Program of CAS[QYZDJ-SSW-SMC020] ; International Partnership Program of CAS[153631KYSB20190013] ; SA-SIBS Scholarship Program
WOS关键词	FUSOBACTERIUM-NUCLEATUM ; COLON-CANCER ; HELICOBACTER-PYLORI ; COLORECTAL-CANCER ; HUMAN HEALTH ; MOUSE MODEL ; BUTYRATE ; INFLAMMATION ; DIVERSITY ; BACTERIA
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	WILEY
WOS记录号	WOS:000626766400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295365]
专题	中国科学院上海药物研究所
通讯作者	Yin, Qi; Li, Yaping
作者单位	1.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China 5.Yantai Key Lab Nanomed & Adv Preparat, Yantai Inst Mat Med, Yantai 264000, Peoples R China
推荐引用方式 GB/T 7714	Zhu, Runqi,Lang, Tianqun,Yan, Wenlu,et al. Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy[J]. ADVANCED SCIENCE,2021:32.
APA	Zhu, Runqi.,Lang, Tianqun.,Yan, Wenlu.,Zhu, Xiao.,Huang, Xin.,...&Li, Yaping.(2021).Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy.ADVANCED SCIENCE,32.
MLA	Zhu, Runqi,et al."Gut Microbiota: Influence on Carcinogenesis and Modulation Strategies by Drug Delivery Systems to Improve Cancer Therapy".ADVANCED SCIENCE (2021):32.