Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity

doi:10.1021/acsnano.1c00033

	Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity
	Wang, Zhiwan 1,2,3; Gong, Xiang 1,2,3; Li, Jie 1,2,3; Wang, Hong 1,2,3; Xu, Xiaoxuan 1,2,3; Li, Yaping 1,2,3; Sha, Xianyi 4; Zhang, Zhiwen 1,2,3,5
刊名	ACS NANO
	2021-03-23
卷号	15 期号:3 页码:5405-5419
关键词	polyfluorocarbon nanovehicle oxygen tumor hypoxia antitumor immunity
ISSN号	1936-0851
DOI	10.1021/acsnano.1c00033
通讯作者	Zhang, Zhiwen()
英文摘要	Hypoxia is a critical cause of tumor immunosuppression, and it significantly limits the efficacy of many anticancer modalities. Herein, we report an amphiphilic F-11-derivative-based oxygen-delivering polyfluorocarbon nanovehicle loading photodynamic DiIC(18)(5) and reactive oxygen species (ROS)-sensitive prodrug of chemo-immunomodulatory gemcitabine (PF(11)DG), aimed at relieving tumor hypoxia and boosting antitumor immunity for cancer therapy. We optimized F-11-based polyfluorocarbon nanovehicles with a 10-fold enhancement of tumor oxygenation. PF(11)DG exhibited intriguing capabilities, such as oxygen-dissolving, ROS production, and responsive drug release. In tumors, PF(11)DG exhibited flexible intratumoral permeation and boosted robust antitumor immune responses upon laser irradiation. Notably, the treatment of PF(11)DG plus laser irradiation (PF(11)DG +L) significantly retarded the tumor growth with an 82.96% inhibition in the 4T1 breast cancer model and a 93.6% inhibition in the PANC02 pancreatic cancer model with better therapeutic benefits than non-oxygen-delivering nanovehicles. Therefore, this study presents an encouraging polyfluorocarbon nanovehicle with deep tumor-penetrating and hypoxia-relieving capacity to boost antitumor immunity for cancer treatment.
资助项目	National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000634569100147
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295253]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Zhiwen
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Fudan Univ, Sch Pharm, Shanghai 201203, Peoples R China 5.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Zhiwan,Gong, Xiang,Li, Jie,et al. Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity[J]. ACS NANO,2021,15(3):5405-5419.
APA	Wang, Zhiwan.,Gong, Xiang.,Li, Jie.,Wang, Hong.,Xu, Xiaoxuan.,...&Zhang, Zhiwen.(2021).Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity.ACS NANO,15(3),5405-5419.
MLA	Wang, Zhiwan,et al."Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity".ACS NANO 15.3(2021):5405-5419.